학술논문
Integrative genome-wide gene expression profiling of clear cell renal cell carcinoma in Czech Republic and in the United States.
Document Type
article
Author
Source
PLoS ONE, Vol 8, Iss 3, p e57886 (2013)
Subject
Language
English
ISSN
1932-6203
Abstract
Gene expression microarray and next generation sequencing efforts on conventional, clear cell renal cell carcinoma (ccRCC) have been mostly performed in North American and Western European populations, while the highest incidence rates are found in Central/Eastern Europe. We conducted whole-genome expression profiling on 101 pairs of ccRCC tumours and adjacent non-tumour renal tissue from Czech patients recruited within the "K2 Study", using the Illumina HumanHT-12 v4 Expression BeadChips to explore the molecular variations underlying the biological and clinical heterogeneity of this cancer. Differential expression analysis identified 1650 significant probes (fold change ≥2 and false discovery rate