학술논문
Genetic determinants of lipid traits in diverse populations from the population architecture using genomics and epidemiology (PAGE) study.
Document Type
article
Author
Logan Dumitrescu; Cara L Carty; Kira Taylor; Fredrick R Schumacher; Lucia A Hindorff; José L Ambite; Garnet Anderson; Lyle G Best; Kristin Brown-Gentry; Petra Bůžková; Christopher S Carlson; Barbara Cochran; Shelley A Cole; Richard B Devereux; Dave Duggan; Charles B Eaton; Myriam Fornage; Nora Franceschini; Jeff Haessler; Barbara V Howard; Karen C Johnson; Sandra Laston; Laurence N Kolonel; Elisa T Lee; Jean W MacCluer; Teri A Manolio; Sarah A Pendergrass; Miguel Quibrera; Ralph V Shohet; Lynne R Wilkens; Christopher A Haiman; Loïc Le Marchand; Steven Buyske; Charles Kooperberg; Kari E North; Dana C Crawford
Source
PLoS Genetics, Vol 7, Iss 6, p e1002138 (2011)
Subject
Language
English
ISSN
1553-7390
1553-7404
1553-7404
Abstract
For the past five years, genome-wide association studies (GWAS) have identified hundreds of common variants associated with human diseases and traits, including high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglyceride (TG) levels. Approximately 95 loci associated with lipid levels have been identified primarily among populations of European ancestry. The Population Architecture using Genomics and Epidemiology (PAGE) study was established in 2008 to characterize GWAS-identified variants in diverse population-based studies. We genotyped 49 GWAS-identified SNPs associated with one or more lipid traits in at least two PAGE studies and across six racial/ethnic groups. We performed a meta-analysis testing for SNP associations with fasting HDL-C, LDL-C, and ln(TG) levels in self-identified European American (~20,000), African American (~9,000), American Indian (~6,000), Mexican American/Hispanic (~2,500), Japanese/East Asian (~690), and Pacific Islander/Native Hawaiian (~175) adults, regardless of lipid-lowering medication use. We replicated 55 of 60 (92%) SNP associations tested in European Americans at p