학술논문
T-cell activation state differentially contributes to neuropsychiatric complications in women with HIV
Document Type
article
Author
Dionna W. Williams; Bianca R. Flores; Yanxun Xu; Yuezhe Wang; Danyang Yu; Brandilyn A. Peters; Adebola Adedimeji; Tracey E. Wilson; Daniel Merenstein; Phyllis C. Tien; Mardge H. Cohen; Kathleen M. Weber; Adaora A. Adimora; Igho Ofotokun; Margaret Fischl; Janet Turan; Bülent Turan; Geoffroy Laumet; Alan L. Landay; Raha M. Dastgheyb; Stephen J. Gange; Sheri D. Weiser; Leah H. Rubin
Source
Brain, Behavior, & Immunity - Health, Vol 25, Iss , Pp 100498- (2022)
Subject
Language
English
ISSN
2666-3546
Abstract
Neuropsychiatric complications are common among women with HIV (WWH). The pathophysiological mechanisms underlying these complications are not fully known but likely driven in part by immune modulation. We examined associations between T-cell activation states which are required to mount an effective immune response (activation, co-stimulation/normal function, exhaustion, senescence) and neuropsychiatric complications in WWH. 369 WWH (78% HIV RNA undetectable/