학술논문
Spidroin N-terminal domain forms amyloid-like fibril based hydrogels and provides a protein immobilization platform
Document Type
article
Author
Tina Arndt; Kristaps Jaudzems; Olga Shilkova; Juanita Francis; Mathias Johansson; Peter R. Laity; Cagla Sahin; Urmimala Chatterjee; Nina Kronqvist; Edgar Barajas-Ledesma; Rakesh Kumar; Gefei Chen; Roger Strömberg; Axel Abelein; Maud Langton; Michael Landreh; Andreas Barth; Chris Holland; Jan Johansson; Anna Rising
Source
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Recombinant spider silks are of interest but the multimodal and aggregation-prone nature of them is a limitation. Here, the authors report on a miniature spidroin based on the N-terminal domain which forms a hydrogel at 37 °C which allows for ease of production and fusion protein modification to generate functional biomaterials.