학술논문
The Role of Ceramide Synthases in the Pathogenicity of Cryptococcus neoformans
Document Type
article
Author
Source
Cell Reports, Vol 22, Iss 6, Pp 1392-1400 (2018)
Subject
Language
English
ISSN
2211-1247
Abstract
Summary: Cryptococcus neoformans (C. neoformans) is estimated to cause about 220,000 new cases every year in patients with AIDS, despite advances in antifungal treatments. C. neoformans possesses a remarkable ability to disseminate through an immunocompromised host, making treatment difficult. Here, we examine the mechanism of survival of C. neoformans under varying host conditions and find a role for ceramide synthase in C. neoformans virulence. This study also provides a detailed lipidomics resource for the fungal lipid research community in addition to discovering a potential target for antifungal therapy.