학술논문
Residential green space in association with the methylation status in a CpG site within the promoter region of the placental serotonin receptor HTR2A
Document Type
article
Author
Source
Epigenetics, Vol 17, Iss 13, Pp 1863-1874 (2022)
Subject
Language
English
ISSN
1559-2294
1559-2308
15592294
1559-2308
15592294
Abstract
Green space could influence adult cognition and childhood neurodevelopment , and is hypothesized to be partly driven by epigenetic modifications. However, it remains unknown whether some of these associations are already evident during foetal development. Similar biological signals shape the developmental processes in the foetal brain and placenta.Therefore, we hypothesize that green space can modify epigenetic processes of cognition-related pathways in placental tissue, such as DNA-methylation of the serotonin receptor HTR2A. HTR2A-methylation was determined within 327 placentas from the ENVIRONAGE (ENVIRonmental influence ON early AGEing) birth cohort using bisulphite-PCR-pyrosequencing. Total green space exposure was calculated using high-resolution land cover data derived from the Green Map of Flanders in seven buffers (50 m-3 km) and stratified into low (