학술논문
Application of anti-inflammatory treatment in two different ovine Acute Respiratory Distress Syndrome injury models: a preclinical randomized intervention study
Document Type
article
Author
Karin Wildi; Samantha Livingstone; Carmen Ainola; Sebastiano Maria Colombo; Silver Heinsar; Noriko Sato; Kei Sato; Mahé Bouquet; Emily Wilson; Gabriella Abbate; Margaret Passmore; Kieran Hyslop; Keibun Liu; Xiaomeng Wang; Chiara Palmieri; Louise E. See Hoe; Jae-Seung Jung; Katrina Ki; Christian Mueller; John Laffey; Paolo Pelosi; Gianluigi Li Bassi; Jacky Suen; John Fraser
Source
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Subject
Language
English
ISSN
2045-2322
Abstract
Abstract Whilst the presence of 2 subphenotypes among the heterogenous Acute Respiratory Distress Syndrome (ARDS) population is becoming clinically accepted, subphenotype-specific treatment efficacy has yet to be prospectively tested. We investigated anti-inflammatory treatment in different ARDS models in sheep, previously shown similarities to human ARDS subphenotypes, in a preclinical, randomized, blinded study. Thirty anesthetized sheep were studied up to 48 h and randomized into: (a) OA: oleic acid (n = 15) and (b) OA-LPS: oleic acid and subsequent lipopolysaccharide (n = 15) to achieve a PaO2/FiO2 ratio of