학술논문
IgG-like bispecific antibodies with potent and synergistic neutralization against circulating SARS-CoV-2 variants of concern
Document Type
article
Author
Matthew R. Chang; Luke Tomasovic; Natalia A. Kuzmina; Adam J. Ronk; Patrick O. Byrne; Rebecca Johnson; Nadia Storm; Eduardo Olmedillas; Yixuan J. Hou; Alexandra Schäfer; Sarah R. Leist; Longping V. Tse; Hanzhong Ke; Christian Coherd; Katrina Nguyen; Maliwan Kamkaew; Anna Honko; Quan Zhu; Galit Alter; Erica Ollmann Saphire; Jason S. McLellan; Anthony Griffiths; Ralph S. Baric; Alexander Bukreyev; Wayne A. Marasco
Source
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
COVID-19 can be treated with monoclonal antibodies against SARS-CoV-2, but emerging new variants might show resistance towards existing therapy. Here authors show that anti-SARS-CoV-2 spike human single-chain antibody fragments could gain neutralizing activity against variants of concern upon engineering into a human bispecific antibody.