학술논문
Multifunctional nanoparticle potentiates the in situ vaccination effect of radiation therapy and enhances response to immune checkpoint blockade
Document Type
article
Author
Ying Zhang; Raghava N. Sriramaneni; Paul A. Clark; Justin C. Jagodinsky; Mingzhou Ye; Wonjong Jin; Yuyuan Wang; Amber Bates; Caroline P. Kerr; Trang Le; Raad Allawi; Xiuxiu Wang; Ruosen Xie; Thomas C. Havighurst; Ishan Chakravarty; Alexander L. Rakhmilevich; Kathleen A. O’Leary; Linda A. Schuler; Paul M. Sondel; Kyungmann Kim; Shaoqin Gong; Zachary S. Morris
Source
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Subject
Language
English
ISSN
2041-1723
Abstract
Radiotherapy can activate an in situ vaccine response and promote response to immune checkpoint inhibitors. Here the authors design a multifunctional nanoparticle to enhance tumor antigen presentation and modulate the tumor immune microenvironment following radiotherapy, showing improved anti-tumor immune responses in radiotherapy-treated tumors when combined with immune checkpoint inhibitors.