학술논문
The role of sentinel node tumor burden in modeling the prognosis of melanoma patients with positive sentinel node biopsy: an Italian melanoma intergroup study (N = 2,086)
Document Type
article
Author
Saveria Tropea; Paolo Del Fiore; Andrea Maurichi; Roberto Patuzzo; Mario Santinami; Simone Ribero; Pietro Quaglino; Virginia Caliendo; Lorenzo Borgognoni; Serena Sestini; Giuseppe Giudice; Eleonora Nacchiero; Corrado Caracò; Adriana Cordova; Nicola Solari; Dario Piazzalunga; Francesca Tauceri; Paolo Carcoforo; Maurizio Lombardo; Sara Cavallari; Simone Mocellin; Italian Melanoma Intergroup (IMI)
Source
BMC Cancer, Vol 22, Iss 1, Pp 1-7 (2022)
Subject
Language
English
ISSN
1471-2407
Abstract
Abstract Background The management of melanoma patients with metastatic melanoma in the sentinel nodes (SN) is evolving based on the results of trials questioning the impact of completion lymph node dissection (CLND) and demonstrating the efficacy of new adjuvant treatments. In this landscape, new prognostic tools for fine risk stratification are eagerly sought to optimize the therapeutic path of these patients. Methods A retrospective cohort of 2,086 patients treated with CLND after a positive SN biopsy in thirteen Italian Melanoma Centers was reviewed. Overall survival (OS) was the outcome of interest; included independent variables were the following: age, gender, primary melanoma site, Breslow thickness, ulceration, sentinel node tumor burden (SNTB), number of positive SN, non-sentinel lymph nodes (NSN) status. Univariate and multivariate survival analyses were performed using the Cox proportional hazard regression model. Results The 3-year, 5-year and 10-year OS rates were 79%, 70% and 54%, respectively. At univariate analysis, all variables, except for primary melanoma body site, were found to be statistically significant prognostic factors. Multivariate Cox regression analysis indicated that older age (P