학술논문
Glucose tolerance and insulin sensitivity define adipocyte transcriptional programs in human obesity
Document Type
article
Author
Source
Molecular Metabolism, Vol 18, Iss , Pp 42-50 (2018)
Subject
Language
English
ISSN
2212-8778
Abstract
Objective: Although debated, metabolic health characterizes 10–25% of obese individuals and reduces risk of developing life-threatening co-morbidities. Adipose tissue is a recognized endocrine organ important for the maintenance of whole-body metabolic health. Adipocyte transcriptional signatures of healthy and unhealthy obesity are largely unknown. Methods: Here, we used a small cohort of highly characterized obese individuals discordant for metabolic health, characterized their adipocytes transcriptional signatures, and cross-referenced them to mouse phenotypic and human GWAs databases. Results and conclusions: Our study showed that glucose intolerance and insulin resistance co-operate to remodel adipocyte transcriptome. We also identified the Nuclear Export Mediator Factor (NEMF) and the Ectoderm-Neural Cortex 1 (ENC1) as novel potential targets in the management of metabolic health in human obesity. Keywords: Obesity, Glucose tolerance, Insulin sensitivity, Transcriptomics, Mouse genetics, Systemic phenotyping