학술논문
可溶性环氧化物水解酶抑制剂对内皮祖细胞归巢功能的影响 / Soluble epoxide hydrolase inhibitors effects on endothelial progenitor cells homing function
Document Type
Academic Journal
Author
Source
重庆医学 / Chongqing Medicine. (35):4900-4903
Subject
Language
Chinese
ISSN
1671-8348
Abstract
目的：研究不同浓度可溶性环氧化物水解酶抑制剂t‐AUCB调节小鼠来源内皮祖细胞（EPCs）归巢功能。方法密度梯度离心法分离培养小鼠骨髓来源EPCs ，不同浓度t‐AUCB预干预EPCs ，检测归巢至小鼠心脏梗死区、边缘区及正常区EPCs细胞数。结果从0～100μmol／L ，随着浓度增加，归巢至上述区域的细胞数量明显增多（P＜0．05）。结论可溶性环氧化物水解酶抑制剂t‐AUCB可呈浓度依赖性参与正向调控EPCs归巢功能。
Objective To observe different concentrations of soluble epoxide hydrolase inhibitor t‐AUCB regulating murine endothelial progenitor cells(EPCs) homing function .Methods We separated by density gradient centrifugation to obtain mouse bone marrow progenitor cells ,different concentrations of t‐AUCB pre‐intervention endothelial progenitor cells ,after the intervention detection EPCs number of homing to the mice cardiac infarction area ,edge area and normal area .Results From 0 to 100 μmol/L ,as the concentration increases ,the number of cells homing to the above‐mentioned regions increased significantly(P<0 .05) .Conclu‐sion Soluble epoxide hydrolase inhibitor t‐AUCB can participate in a concentration‐dependent positive regulation of EPCs homing function .
Objective To observe different concentrations of soluble epoxide hydrolase inhibitor t‐AUCB regulating murine endothelial progenitor cells(EPCs) homing function .Methods We separated by density gradient centrifugation to obtain mouse bone marrow progenitor cells ,different concentrations of t‐AUCB pre‐intervention endothelial progenitor cells ,after the intervention detection EPCs number of homing to the mice cardiac infarction area ,edge area and normal area .Results From 0 to 100 μmol/L ,as the concentration increases ,the number of cells homing to the above‐mentioned regions increased significantly(P<0 .05) .Conclu‐sion Soluble epoxide hydrolase inhibitor t‐AUCB can participate in a concentration‐dependent positive regulation of EPCs homing function .