학술논문
Functional Preconcentration Tip of Total Volume Injection for ESI/MS Analysis of DNA Adducts
Document Type
Article
Source
Analytical Sciences; February 2011, Vol. 27 Issue: 2 p217-220, 4p
Subject
Language
ISSN
09106340; 13482246
Abstract
We have developed a simple method to significantly improve the sensitivity in the LC/MS analysis of DNA adducts. A preconcentration tip for the selective recovery of DNA adducts was prepared. Using this tip, the total amount of DNA adducts in a treated DNA sample was injected in a one-shot manner into an LC/MS system. We were able to improve the sensitivity by more than one order of magnitude in concentration. This method will be a useful tool for the quantitative determination of trace DNA adducts.