학술논문
Epitope spreading toward wild-type melanocyte-lineage antigens rescues suboptimal immune checkpoint blockade responses
Document Type
Article
Author
Lo, Jennifer A.; Kawakubo, Masayoshi; Juneja, Vikram R.; Su, Mack Y.; Erlich, Tal H.; LaFleur, Martin W.; Kemeny, Lajos V.; Rashid, Mamunur; Malehmir, Mohsen; Rabi, S. Alireza; Raghavan, Rumya; Allouche, Jennifer; Kasumova, Gyulnara; Frederick, Dennie T.; Pauken, Kristen E.; Weng, Qing Yu; Pereira da Silva, Marcelo; Xu, Yu; van der Sande, Anita A. J.; Silkworth, Whitney; Roider, Elisabeth; Browne, Edward P.; Lieb, David J.; Wang, Belinda; Garraway, Levi A.; Wu, Catherine J.; Flaherty, Keith T.; Brinckerhoff, Constance E.; Mullins, David W.; Adams, David J.; Hacohen, Nir; Hoang, Mai P.; Boland, Genevieve M.; Freeman, Gordon J.; Sharpe, Arlene H.; Manstein, Dieter; Fisher, David E.
Source
Science Translational Medicine; February 2021, Vol. 13 Issue: 581
Subject
Language
ISSN
19466234; 19466242
Abstract
Neoantigens sensitize melanomas to checkpoint blockade and trigger epitope spreading to self-antigens, a process mimicked by combination immunotherapy.