학술논문
The All of UsResearch Program: Data quality, utility, and diversity
Document Type
Article
Author
Ramirez, Andrea H.; Sulieman, Lina; Schlueter, David J.; Halvorson, Alese; Qian, Jun; Ratsimbazafy, Francis; Loperena, Roxana; Mayo, Kelsey; Basford, Melissa; Deflaux, Nicole; Muthuraman, Karthik N.; Natarajan, Karthik; Kho, Abel; Xu, Hua; Wilkins, Consuelo; Anton-Culver, Hoda; Boerwinkle, Eric; Cicek, Mine; Clark, Cheryl R.; Cohn, Elizabeth; Ohno-Machado, Lucila; Schully, Sheri D.; Ahmedani, Brian K.; Argos, Maria; Cronin, Robert M.; O’Donnell, Christopher; Fouad, Mona; Goldstein, David B.; Greenland, Philip; Hebbring, Scott J.; Karlson, Elizabeth W.; Khatri, Parinda; Korf, Bruce; Smoller, Jordan W.; Sodeke, Stephen; Wilbanks, John; Hentges, Justin; Mockrin, Stephen; Lunt, Christopher; Devaney, Stephanie A.; Gebo, Kelly; Denny, Joshua C.; Carroll, Robert J.; Glazer, David; Harris, Paul A.; Hripcsak, George; Philippakis, Anthony; Roden, Dan M.; Ahmedani, Brian; Cole Johnson, Christine D.; Ahsan, Habib; Antoine-LaVigne, Donna; Singleton, Glendora; Anton-Culver, Hoda; Topol, Eric; Baca-Motes, Katie; Steinhubl, Steven; Wade, James; Begale, Mark; Jain, Praduman; Sutherland, Scott; Lewis, Beth; Korf, Bruce; Behringer, Melissa; Gharavi, Ali G.; Goldstein, David B.; Hripcsak, George; Bier, Louise; Boerwinkle, Eric; Brilliant, Murray H.; Murali, Narayana; Hebbring, Scott Joseph; Farrar-Edwards, Dorothy; Burnside, Elizabeth; Drezner, Marc K.; Taylor, Amy; Channamsetty, Veena; Montalvo, Wanda; Sharma, Yashoda; Chinea, Carmen; Jenks, Nancy; Cicek, Mine; Thibodeau, Steve; Holmes, Beverly Wilson; Schlueter, Eric; Collier, Ever; Winkler, Joyce; Corcoran, John; D’Addezio, Nick; Daviglus, Martha; Winn, Robert; Wilkins, Consuelo; Roden, Dan; Denny, Joshua; Doheny, Kim; Nickerson, Debbie; Eichler, Evan; Jarvik, Gail; Funk, Gretchen; Philippakis, Anthony; Rehm, Heidi; Lennon, Niall; Kathiresan, Sekar; Gabriel, Stacey; Gibbs, Richard; Gil Rico, Edgar M.; Glazer, David; Grand, Joannie; Greenland, Philip; Harris, Paul; Shenkman, Elizabeth; Hogan, William R.; Igho-Pemu, Priscilla; Pollan, Cliff; Jorge, Milena; Okun, Sally; Karlson, Elizabeth W.; Smoller, Jordan; Murphy, Shawn N.; Ross, Margaret Elizabeth; Kaushal, Rainu; Winford, Eboni; Wallace, Febe; Khatri, Parinda; Kheterpal, Vik; Ojo, Akinlolu; Moreno, Francisco A.; Kron, Irving; Peterson, Rachele; Menon, Usha; Lattimore, Patricia Watkins; Leviner, Noga; Obedin-Maliver, Juno; Lunn, Mitchell; Malik-Gagnon, Lynda; Mangravite, Lara; Marallo, Adria; Marroquin, Oscar; Visweswaran, Shyam; Reis, Steven; Marshall, Gailen; McGovern, Patrick; Mignucci, Deb; Moore, John; Munoz, Fatima; Talavera, Gregory; O'Connor, George T.; O'Donnell, Christopher; Ohno-Machado, Lucila; Orr, Greg; Randal, Fornessa; Theodorou, Andreas A.; Reiman, Eric; Roxas-Murray, Mercedita; Stark, Louisa; Tepp, Ronnie; Zhou, Alicia; Topper, Scott; Trousdale, Rhonda; Tsao, Phil; Weidman, Lisa; Weiss, Scott T.; Wellis, David; Whittle, Jeffrey; Wilson, Amanda; Zuchner, Stephan; Zwick, Michael E.
Source
Patterns; August 2022, Vol. 3 Issue: 8
Subject
Language
ISSN
26663899
Abstract
The All of UsResearch Program seeks to engage at least one million diverse participants to advance precision medicine and improve human health. We describe here the cloud-based Researcher Workbench that uses a data passport model to democratize access to analytical tools and participant information including survey, physical measurement, and electronic health record (EHR) data. We also present validation study findings for several common complex diseases to demonstrate use of this novel platform in 315,000 participants, 78% of whom are from groups historically underrepresented in biomedical research, including 49% self-reporting non-White races. Replication findings include medication usage pattern differences by race in depression and type 2 diabetes, validation of known cancer associations with smoking, and calculation of cardiovascular risk scores by reported race effects. The cloud-based Researcher Workbench represents an important advance in enabling secure access for a broad range of researchers to this large resource and analytical tools.