학술논문
Prolonged Immunosuppression and Tumor Induction by a Chemical Carcinogen Injected at Birth
Document Type
Article
Author
Source
Science; April 1966, Vol. 152 Issue: 3722 p650-651, 2p
Subject
Language
ISSN
00368075; 10959203
Abstract
The injection of 60 micrograms of 9,10-dimethyl-1,2-benzanthracene into newborn mice gave rise to a very high incidence of malignant thymomas. The tumor incidence was directly related to the dose of the carcinogen. The neonatal injection of the carcinogen also resulted in a depression in the immune response when the animals were challenged with an antigen as early as 4 weeks or as late as 11 weeks after administration of the carcinogen.