학술논문
Global Levels of Specific Histone Modifications and an Epigenetic Gene Signature Predict Prostate Cancer Progression and Development.
Document Type
Article
Author
Bianco-Miotto, Tina; Chiam, Karen; Buchanan, Grant; Jindal, Shalini; Day, Tanya K.; Thomas, Mervyn; Pickering, Marie A.; O'Loughlin, Melissa A.; Ryan, Natalie K.; Raymond, Wendy A.; Horvath, Lisa G.; Kench, James G.; Stricker, Phillip D.; Marshall, Villis R.; Sutherland, Robert L.; Henshall, Susan M.; Gerald, William L.; Scher, Howard I.; Risbridger, Gail P.; Clements, Judith A.
Source
Cancer Epidemiology, Biomarkers & Prevention; Oct2010, Vol. 19 Issue 10, p2611-2622, 12p, 2 Charts, 4 Graphs
Subject
Language
ISSN
10559965
Abstract
The article discusses research on whether specific histone modifications are prognostic for prostate cancer relapse and whether prostate tumorigenesis changes the expression of epigenetic genes. A prostate cancer cohort of 279 cases was used to assess immunohistochemically global levels of histone H3 lysine-18 acetylation (H3K18Ac) and histone H3 lysine-4 dimethylation (H3K4diMe). Findings revealed the prognostic potential of histone modifications in prostate cancer and its importance in predicting individual patient response to epigenetic therapies.