부산대학교 도서관

Cyclooxygenase (COX)‐2 inhibitors are widely prescribed for their antiinflammatory and analgesic effects. The potential for COX‐2 inhibitors to exert deleterious effects on renal function similar to those of traditional nonsteroidal antiinflammatory drugs is not well defined. Until recently, COX‐1 was considered responsible for the synthesis of renal prostaglandins. However, COX‐2 is also constitutively expressed in the human kidney Clinical studies have reported a significant decrease in glomerular filtration rate in young and elderly sodium‐depleted volunteers given COX‐2 inhibitors. We describe the case of a 71‐year‐old woman who developed acute renal failure after receiving a 50‐mg dose of the selective COX‐2 inhibitor rofecoxib.