학술논문
The Impact of Vaccination on Incidence and Outcomes of SARS-CoV-2 Infection in Patients with Kidney Failure in Scotland
Document Type
Article
Author
Bell, Samira; Campbell, Jacqueline; Lambourg, Emilie; Watters, Chrissie; O?Neil, Martin; Almond, Alison; Buck, Katharine; Carr, Edward J.; Clark, Laura; Cousland, Zoe; Findlay, Mark; Joss, Nicola; Metcalfe, Wendy; Petrie, Michaela; Spalding, Elaine; Traynor, Jamie P.; Sanu, Vinod; Thomson, Peter; Methven, Shona; Mark, Patrick B.
Source
Journal of the American Society of Nephrology; April 2022, Vol. 33 Issue: 4 p677-686, 10p
Subject
Language
ISSN
10466673; 15333450
Abstract
Patients with kidney failure requiring KRT are at high risk of poor outcomes following SARS-CoV-2 infection, with variable antibody responses to vaccination reported. Ninety-three percent of patients on KRT in Scotland received a SARS-CoV-2 vaccine. The effectiveness of two vaccine doses was only 33% (95% CI, 0 to 52) against SARS-CoV-2 infection and 38% (95% CI, 0 to 57) against hospitalization in patients requiring KRT. Within 28 days of a positive SARS-CoV-2 PCR test, 9.2% of fully vaccinated patients died (7% patients on dialysis and 10% transplant recipients). These data suggest that a primary vaccine course of two doses does not provide adequate protection in patients receiving KRT and highlight the urgent need for adjunctive strategies to reduce risk of both SARS-CoV-2 infection and its complications.