부산대학교 도서관

ABSTRACTCDC coryneform group A-3 bacteria are rare human pathogens. In this study, six group A-3 isolates (two from blood, one from cerebrospinal fluid, and one each from homograft valve, lip wound, and pilonidal cyst) were compared to the type strains of phenotypically related organisms, Cellulomonas fimi, Cellulomonas hominis, Oerskovia turbata, and Sanguibacter suarezii, and characterized by phenotypic, chemotaxonomic, and genotypic studies. DNA-DNA reassociation analysis identified two genomic groups, and phylogenetic analysis of the 16S rRNA gene sequence identified the taxonomic positions of these groups to genus level. Two groups were defined, and both were more closely related to Cellulomonasspecies: one group of three strains, for which we propose the new species Cellulomonas denverensissp. nov., with the type strain W6929 (ATCC BAA-788Tor DSM 15764T), was related to C. hominisATCC 51964T(98.5% 16S rRNA gene sequence similarity), and the second group of three strains was related to C. hominisATCC 51964T(99.8 to 99.9% 16S rRNA gene sequence similarity). The definition of this new Cellulomonasspecies and the confirmation of three strains as C. hominisserve to further clarify the complex taxonomy of CDC coryneform group A-3 bacteria and will assist in our understanding of the epidemiology and clinical significance of these microorganisms.