학술논문
Efficient Synthesis of Thioesters and Amides from Aldehydes by Using an Intermolecular Radical Reaction in Water
Document Type
Article
Source
Chemistry - A European Journal; January 2005, Vol. 11 Issue: 2 p719-727, 9p
Subject
Language
ISSN
09476539; 15213765
Abstract
The combination of the water‐soluble radical initiator, 2,2′‐azobis[2‐(2‐imidazolin‐2‐yl)propane] dihydrochloride (VA‐044) and the surfactant, cetyltrimethyl‐ammonium bromide (CTAB), was found to be the most suitable condition for the effective and direct synthesis of useful active thioesters (pentafluorophenyl thioesters) in water. In addition, the direct amidation of aldehydes was achieved by the addition of the amines to the thioesterification reaction mixture in water.