학술논문
The laboratory parameters-derived CoLab score as an indicator of the host response in ICU COVID-19 patients decreases over time: a prospective cohort study.
Document Type
Academic Journal
Author
Schoenmakers T; Department of Clinical Chemistry and Hematology, Zuyderland Medical Center, Sittard-Geleen, Dr. H. Van Der Hoffplein 1, 6162 BG, Sittard-Geleen, The Netherlands. t.schoenmakers@zuyderland.nl.; School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, The Netherlands. t.schoenmakers@zuyderland.nl.; Department of Intensive Care Medicine, Maastricht University Medical Center +, Maastricht, The Netherlands. t.schoenmakers@zuyderland.nl.; Leers MPG; Department of Clinical Chemistry and Hematology, Zuyderland Medical Center, Sittard-Geleen, Dr. H. Van Der Hoffplein 1, 6162 BG, Sittard-Geleen, The Netherlands.; School of Nutrition and Translational Research in Metabolism (NUTRIM), Maastricht University, Maastricht, The Netherlands.; Faculty of Science, Environmental Sciences, Open Universiteit, Heerlen, The Netherlands.; Gorissen SHM; Zuyderland Academy, Zuyderland Medical Center, Sittard-Geleen/Heerlen, The Netherlands.; van Loo IHM; Department of Medical Microbiology, Infectious Diseases and Infection Prevention, Maastricht University Medical Center +, Maastricht, The Netherlands.; Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.; van Rosmalen F; Department of Intensive Care Medicine, Maastricht University Medical Center +, Maastricht, The Netherlands.; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.; Aydeniz E; Department of Intensive Care Medicine, Maastricht University Medical Center +, Maastricht, The Netherlands.; Schellens J; Department of Intensive Care Medicine, Maastricht University Medical Center +, Maastricht, The Netherlands.; Driessen M; Department of Intensive Care Medicine, Maastricht University Medical Center +, Maastricht, The Netherlands.; Deneer R; Department of Clinical Chemistry and Hematology, Zuyderland Medical Center, Sittard-Geleen, Dr. H. Van Der Hoffplein 1, 6162 BG, Sittard-Geleen, The Netherlands.; de Venne WPHGV; Department of Clinical Chemistry and Hematology, Zuyderland Medical Center, Sittard-Geleen, Dr. H. Van Der Hoffplein 1, 6162 BG, Sittard-Geleen, The Netherlands.; Wolffs PFG; Department of Medical Microbiology, Infectious Diseases and Infection Prevention, Maastricht University Medical Center +, Maastricht, The Netherlands.; Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.; van Mook WNKA; Department of Intensive Care Medicine, Maastricht University Medical Center +, Maastricht, The Netherlands.; School of Health Professions Education (SHE), Maastricht University, Maastricht, The Netherlands.; van Bussel BCT; Department of Intensive Care Medicine, Maastricht University Medical Center +, Maastricht, The Netherlands.; Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands.; Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Source
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
Subject
Language
English
Abstract
The CoLab score was developed and externally validated to rule out COVID-19 among suspected patients presenting at the emergency department. We hypothesized a within-patient decrease in the CoLab score over time in an intensive care unit (ICU) cohort. Such a decrease would create the opportunity to potentially rule out the need for isolation when the infection is overcome. Using linear mixed-effects models, data from the Maastricht Intensive Care COVID (MaastrICCht) cohort were used to investigate the association between time and the CoLab score. Models were adjusted for sex, APACHE II score, ICU mortality, and daily SOFA score. The CoLab score decreased by 0.30 points per day (95% CI - 0.33 to - 0.27), independent of sex, APACHE II, and Mortality. With increasing SOFA score over time, the CoLab score decreased more strongly (- 0.01 (95% CI - 0.01 to - 0.01) additional decrease per one-point increase in SOFA score.) The CoLab score decreased in ICU patients on mechanical ventilation for COVID-19, with a one-point reduction per three days, independent of sex, APACHE II, and ICU mortality, and somewhat stronger with increasing multi-organ failure over time. This suggests that the CoLab score would decrease below a threshold where COVID-19 can be excluded.
(© 2024. The Author(s).)
(© 2024. The Author(s).)