학술논문
In vitro assessment of the biologic activity of interferon beta formulations used for the treatment of relapsing multiple sclerosis.
Document Type
Academic Journal
Author
Scagnolari C; a Department of Molecular Medicine , Sapienza University of Rome , Rome , Italy.; Selvaggi C; Di Biase E; Fraulo M; Dangond F; Antonelli G
Source
Publisher: Taylor & Francis Country of Publication: England NLM ID: 100963688 Publication Model: Print Cited Medium: Internet ISSN: 1532-4230 (Electronic) Linking ISSN: 15321819 NLM ISO Abbreviation: J Immunoassay Immunochem Subsets: MEDLINE
Subject
Language
English
Abstract
A new formulation (NF) of subcutaneous (sc) interferon (IFN) β-1a was developed in an attempt to improve injection tolerability and immunogenicity. We compared antiviral and IFNβ-stimulated gene (ISG) activities of IFNβ-1a sc NF with IFNβ-1a sc original formulation and IFNβ-1b sc. When equivalent unit amounts were compared, the IFNβ formulations demonstrated similar antiviral activity and induced similar levels of ISG mRNA. However, on a weight basis (ng/mL), significantly more IFNβ-1b sc was needed to equal the antiviral activity of either IFNβ-1a sc formulation, and both IFNβ-1a sc formulations induced significantly higher levels of ISG mRNA than IFNβ-1b sc.