학술논문
Utilities for Type 2 Diabetes Treatment-Related Attributes in a South Korean and Taiwanese Population.
Document Type
Academic Journal
Author
Rajan N; Eli Lilly, Indianapolis, IN, USA. Electronic address: rajan_narayan@lilly.com.; Boye KS; Eli Lilly, Indianapolis, IN, USA.; Gibbs M; Information Fulfillment Ltd., Hong Kong, China.; Lee YJ; Eli Lilly Korea, Seoul, Korea.; Davey P; PRIMA Consulting Group, Sydney, New South Wales, Australia.; Ball M; PRIMA Consulting Group, Sydney, New South Wales, Australia.; Babineaux SM; Eli Lilly, Indianapolis, IN, USA.
Source
Publisher: Elsevier Country of Publication: United States NLM ID: 101592642 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2212-1102 (Electronic) Linking ISSN: 22121099 NLM ISO Abbreviation: Value Health Reg Issues Subsets: MEDLINE
Subject
Language
English
Abstract
Objectives: To elicit utilities associated with type 2 diabetes medication-related attributes from South Korean and Taiwanese populations and to identify key drivers of preferences.
Methods: Data from 59 respondents from the general population in South Korea and Taiwan were analyzed. Respondents' preferences were elicited using a paper-based standard gamble questionnaire. Health states were designed to identify the utility or disutility of type 2 diabetes medication-related attributes, including dose frequency, nausea/vomiting (hereafter referred to as nausea), and weight change.
Results: The mean utility for the basic health state (encompassing current body weight and no nausea) was 0.754 ± 0.155 with weekly dose administration. Respondents showed a preference for weekly over daily administration (average increase in utility of 0.043 across all health states with weekly, vs. daily, administration). Nausea was associated with a decrease in utility (average decrease of -0.034 across all health states with, vs. without, nausea). Weight gain had little effect on utility (average decrease of 0.000 and 0.001 across all health states with, vs. without, 3% and 5% gain, respectively), although weight loss was associated with a small increase in utility (average increase of 0.028 and 0.029 across all health states with, vs. without, 3% and 5% loss, respectively).
Conclusions: Utilities associated with type 2 diabetes medication-related attributes were elicited from a general population sample from South Korea and Taiwan. Treatment-related attributes, in particular dose frequency and nausea, had a measurable effect on utility and should be considered when selecting treatment regimens for South Korean or Taiwanese patients with type 2 diabetes.
(Copyright © 2016 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.)
Methods: Data from 59 respondents from the general population in South Korea and Taiwan were analyzed. Respondents' preferences were elicited using a paper-based standard gamble questionnaire. Health states were designed to identify the utility or disutility of type 2 diabetes medication-related attributes, including dose frequency, nausea/vomiting (hereafter referred to as nausea), and weight change.
Results: The mean utility for the basic health state (encompassing current body weight and no nausea) was 0.754 ± 0.155 with weekly dose administration. Respondents showed a preference for weekly over daily administration (average increase in utility of 0.043 across all health states with weekly, vs. daily, administration). Nausea was associated with a decrease in utility (average decrease of -0.034 across all health states with, vs. without, nausea). Weight gain had little effect on utility (average decrease of 0.000 and 0.001 across all health states with, vs. without, 3% and 5% gain, respectively), although weight loss was associated with a small increase in utility (average increase of 0.028 and 0.029 across all health states with, vs. without, 3% and 5% loss, respectively).
Conclusions: Utilities associated with type 2 diabetes medication-related attributes were elicited from a general population sample from South Korea and Taiwan. Treatment-related attributes, in particular dose frequency and nausea, had a measurable effect on utility and should be considered when selecting treatment regimens for South Korean or Taiwanese patients with type 2 diabetes.
(Copyright © 2016 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.)