학술논문
Full kinetic modeling analysis of [ 18 F]fluorocholine Positron Emission Tomography (PET) at initial diagnosis of high-grade glioma.
Document Type
Academic Journal
Author
Rubí S; Department of Nuclear Medicine, Hospital Universitari Son Espases, 07010 Palma, Spain; Department of Medicine, University of the Balearic Islands, E-07122 Palma, Spain; Health Research Institute of the Balearic Islands (IdISBa), 07010 Palma, Spain. Electronic address: sebastia.rubi@ssib.es.; Bibiloni P; Health Research Institute of the Balearic Islands (IdISBa), 07010 Palma, Spain; SCOPIA Research Group, University of the Balearic Islands, E-07122 Palma, Spain.; Villar M; Department of Nuclear Medicine, Hospital Universitari Son Espases, 07010 Palma, Spain.; Brell M; Department of Medicine, University of the Balearic Islands, E-07122 Palma, Spain; Health Research Institute of the Balearic Islands (IdISBa), 07010 Palma, Spain; Department of Neurosurgery, Hospital Universitari Son Espases, 07010 Palma, Spain.; Valiente M; Department of Nuclear Medicine, Hospital Universitari Son Espases, 07010 Palma, Spain.; Galmés M; Department of Nuclear Medicine, Hospital Quironsalud Palmaplanas, 07010 Palma, Spain.; Toscano M; Department of Nuclear Medicine, Hospital Universitari Son Espases, 07010 Palma, Spain.; Matheu G; Health Research Institute of the Balearic Islands (IdISBa), 07010 Palma, Spain; Department of Pathology, Hospital Universitari Son Espases, 07010 Palma, Spain.; Chinchilla JL; Department of Nuclear Medicine, Hospital Universitari Son Espases, 07010 Palma, Spain.; Molina J; Department of Nuclear Medicine, Hospital Universitari Son Espases, 07010 Palma, Spain.; Luis Valera J; Health Research Institute of the Balearic Islands (IdISBa), 07010 Palma, Spain; Department of Pulmonology, Hospital Universitari Son Espases, 07010 Palma, Spain.; Ríos Á; Health Research Institute of the Balearic Islands (IdISBa), 07010 Palma, Spain.; López M; Health Research Institute of the Balearic Islands (IdISBa), 07010 Palma, Spain.; Peña C; Department of Nuclear Medicine, Hospital Universitari Son Espases, 07010 Palma, Spain; Health Research Institute of the Balearic Islands (IdISBa), 07010 Palma, Spain.
Source
Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101597070 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2213-1582 (Electronic) Linking ISSN: 22131582 NLM ISO Abbreviation: Neuroimage Clin Subsets: MEDLINE
Subject
Language
English
Abstract
Purpose: The main objective was to characterize the tracer uptake kinetics of [ 18 F]fluoromethylcholine ([ 18 F]F-CHO) in high-grade gliomas (HGG) through a full PET kinetic modeling approach. Secondarily, we aimed to explore the relationship between the PET uptake measures and the HGG molecular features.
Materials and Methods: Twenty-four patients with a suspected diagnosis of HGG were prospectively included. They underwent a dynamic brain [18 F]F-CHO-PET/CT, from which a tumoral time-activity curve was extracted. The plasma input function was obtained through arterial blood sampling with metabolite correction. These data were fitted to 1- and 2-tissue-compartment models, the best of which was selected through the Akaike information criterion. We assessed the correlation between the kinetic parameters and the conventional static PET metrics (SUV max , SUV mean and tumor-to-background ratio TBR). We explored the association between the [ 18 F]F-CHO-PET quantitative parameters and relevant molecular biomarkers in HGG.
Results: Tumoral time-activity curves in all patients showed a rapid rise of [18 F]F-CHO uptake followed by a plateau-like shape. Best fits were obtained with near-irreversible 2-tissue-compartment models. The perfusion-transport constant K 1 and the net influx rate K i showed strong correlation with SUV max (r = 0.808-0.861), SUV mean (r = 0.794-0.851) and TBR (r = 0.643-0.784), p < 0.002. HGG was confirmed in 21 patients, of which those with methylation of the O-6-methylguanine-DNA methyltransferase (MGMT) gene promoter showed higher mean K i (p = 0.020), K 1 (p = 0.025) and TBR (p = 0.001) than the unmethylated ones.
Conclusion: [18 F]F-CHO uptake kinetics in HGG is best explained by a 2-tissue-compartment model. The conventional static [ 18 F]F-CHO-PET measures have been validated against the perfusion-transport constant (K 1 ) and the net influx rate (K i ) derived from kinetic modeling. A relationship between [ 18 F]F-CHO uptake rate and MGMT methylation is suggested but needs further confirmation.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
Materials and Methods: Twenty-four patients with a suspected diagnosis of HGG were prospectively included. They underwent a dynamic brain [
Results: Tumoral time-activity curves in all patients showed a rapid rise of [
Conclusion: [
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)