학술논문
Cytotoxic prenylated phenols of false indigo-bush ( Amorpha fruticosa L.).
Document Type
Academic Journal
Author
Samardžić S; Department of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.; Đorđić Crnogorac M; Institute of Oncology and Radiology of Serbia, Belgrade, Serbia.; Petković M; Department of Organic Chemistry, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.; Arsenijević J; Department of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.; Stanojković T; Institute of Oncology and Radiology of Serbia, Belgrade, Serbia.; Maksimović Z; Department of Pharmacognosy, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia.
Source
Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE
Subject
Language
English
Abstract
This study employed the MTT assay to assess the cytotoxicity of one flavan and two stilbene derivatives isolated from the false indigo-bush ( Amorpha fruticosa L.) fruits: 5,7-dihydroxy-8-geranylflavanone ( 1 ), 2-carboxy-3,5-dihydroxy-4-geranylbibenzyl ( 2 ), and 2-carboxy-3-hydroxy-4-prenyl-5-methoxybibenzyl ( 3 ). The examined compounds reduced the survival of human cervical and colon tumour cells (HeLa, HT-29, HCT-116, and LS174) with IC 50 values ranging from 10.55 to 147.09 μg/mL, except for 1 , which did not affect LS174 cells within the tested concentrations. The highest activity was observed for 1 against HeLa cells, and 1 also exhibited the weakest effect against normal foetal lung fibroblasts (IC 50 = 166.11 μg/mL), demonstrating good potency and selectivity. Stilbenes 2 and 3 proved efficacious, but lacked selectivity compared to 1 . Our findings revealed the cytotoxicity of false indigo-bush constituents, justifying further mechanistic and in vivo investigations, particularly on 5,7-dihydroxy-8-geranylflavanone, which displayed considerable in vitro anticancer capacity and a potentially favourable safety profile.