학술논문
Somatic evolution and global expansion of an ancient transmissible cancer lineage.
Document Type
Academic Journal
Author
Baez-Ortega A; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.; Gori K; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.; Strakova A; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.; Allen JL; Animal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia.; Allum KM; World Vets, Gig Harbor, USA.; Bansse-Issa L; Animal Shelter, Stichting Dierenbescherming Suriname, Paramaribo, Suriname.; Bhutia TN; Sikkim Anti-Rabies and Animal Health Programme, Department of Animal Husbandry, Livestock, Fisheries and Veterinary Services, Government of Sikkim, India.; Bisson JL; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.; Royal (Dick) School of Veterinary Studies and the Roslin Institute, University of Edinburgh, Easter Bush Campus, Roslin EH25 9RG, UK.; Briceño C; ConserLab, Animal Preventive Medicine Department, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile.; Castillo Domracheva A; Corozal Veterinary Hospital, University of Panamá, Panama City, Republic of Panama.; Corrigan AM; St. George's University, True Blue, Grenada.; Cran HR; The Nakuru District Veterinary Scheme Ltd, Nakuru, Kenya.; Crawford JT; Animal Medical Centre, Belize City, Belize.; Davis E; International Animal Welfare Training Institute, UC Davis School of Veterinary Medicine, Davis, CA, USA.; de Castro KF; Centro Universitário de Rio Preto (UNIRP), São José do Rio Preto, São Paulo, Brazil.; B de Nardi A; Department of Clinical and Veterinary Surgery, São Paulo State University (UNESP), São Paulo, Brazil.; de Vos AP; Ladybrand Animal Clinic, Ladybrand, South Africa.; Delgadillo Keenan L; Veterinary Clinic Sr. Dog's, Guadalajara, Mexico.; Donelan EM; Animal Management in Rural and Remote Indigenous Communities (AMRRIC), Darwin, Australia.; Espinoza Huerta AR; World Vets Latin America Veterinary Training Center, Granada, Nicaragua.; Faramade IA; National Veterinary Research Institute, Vom, Nigeria.; Fazil M; Animal Clinic, Mombasa, Kenya.; Fotopoulou E; Intermunicipal Stray Animals Care Centre (DIKEPAZ), Perama, Greece.; Fruean SN; Animal Protection Society of Samoa, Apia, Samoa.; Gallardo-Arrieta F; Faculty of Veterinary Science, University of Zulia, Maracaibo, Venezuela.; Glebova O; Veterinary Clinic BIOCONTROL, Moscow, Russia.; Gouletsou PG; Faculty of Veterinary Medicine, School of Health Sciences, University of Thessaly, Karditsa, Greece.; Häfelin Manrique RF; Veterinary Clinic El Roble, Animal Healthcare Network, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago de Chile, Chile.; Henriques JJGP; OnevetGroup, Hospital Veterinário Berna, Lisboa, Portugal.; Horta RS; Universidade Vila Velha, Vila Velha, Brazil.; Ignatenko N; Veterinary Clinic Zoovetservis, Kiev, Ukraine.; Kane Y; École Inter-états des Sciences et Médecine Vétérinaires de Dakar, Dakar, Senegal.; King C; World Vets, Gig Harbor, USA.; Koenig D; World Vets, Gig Harbor, USA.; Krupa A; Department of Small Animal Medicine, Faculty of Veterinary Medicine, Utrecht University, Utrecht, Netherlands.; Kruzeniski SJ; World Vets Latin America Veterinary Training Center, Granada, Nicaragua.; Kwon YM; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.; Lanza-Perea M; St. George's University, True Blue, Grenada.; Lazyan M; Vetexpert Veterinary Group, Yerevan, Armenia.; Lopez Quintana AM; Veterinary Clinic Lopez Quintana, Maldonado, Uruguay.; Losfelt T; Clinique Veterinaire de Grand Fond, Saint Gilles les Bains, Reunion, France.; Marino G; Department of Veterinary Sciences, University of Messina, Messina, Italy.; Martínez Castañeda S; Facultad de Medicina Veterinaria y Zootecnia, Universidad Autónoma del Estado de México, Toluca, Mexico.; Martínez-López MF; School of Veterinary Medicine, Universidad de las Américas, Quito, Ecuador.; Cancer Development and Innate Immune Evasion Lab, Champalimaud Center for the Unknown, Lisbon, Portugal.; Meyer M; Touray & Meyer Vet Clinic, Serrekunda, The Gambia.; Migneco EJ; Hillside Animal Hospital, St. Louis, MO, USA.; Nakanwagi B; The Kampala Veterinary Surgery, Kampala, Uganda.; Neal KB; Asavet Veterinary Charities, Tucson, AZ, USA.; Neunzig W; World Vets, Gig Harbor, USA.; Ní Leathlobhair M; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.; Nixon SJ; Vets Beyond Borders, Bylakuppe, India.; Ortega-Pacheco A; Faculty of Veterinary Medicine, Autonomous University of Yucatan, Merida, Mexico.; Pedraza-Ordoñez F; Laboratorio de Patología Veterinaria, Universidad de Caldas, Manizales, Colombia.; Peleteiro MC; Interdisciplinary Centre of Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, Lisboa, Portugal.; Polak K; Four Paws International, Vienna, Austria.; Pye RJ; Vets Beyond Borders, The Rocks, Australia.; Reece JF; Help in Suffering, Jaipur, India.; Rojas Gutierrez J; Veterinary Clinic Dr José Rojas, Los Andes, Chile.; Sadia H; Department of Biotechnology, Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Pakistan.; Schmeling SK; Corozal Veterinary Clinic, Corozal Town, Belize.; Shamanova O; Veterinary Clinic Vetmaster, Ramenskoye, Russia.; Sherlock AG; Vets Beyond Borders, The Rocks, Australia.; Stammnitz M; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.; Steenland-Smit AE; Animal Shelter, Stichting Dierenbescherming Suriname, Paramaribo, Suriname.; Svitich A; State Hospital of Veterinary Medicine, Dniprodzerzhynsk, Ukraine.; Tapia Martínez LJ; World Vets Latin America Veterinary Training Center, Granada, Nicaragua.; Thoya Ngoka I; Jomo Kenyatta University of Agriculture and Technology, Juja, Kenya.; Torres CG; Laboratory of Biomedicine and Regenerative Medicine, Department of Clinical Sciences, Faculty of Animal and Veterinary Sciences, University of Chile, Santiago, Chile.; Tudor EM; Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Melbourne, Australia.; van der Wel MG; Animal Anti Cruelty League, Port Elizabeth, South Africa.; Viţălaru BA; Clinical Sciences Department, Faculty of Veterinary Medicine Bucharest, Bucharest, Romania.; Vural SA; Department of Pathology, Faculty of Veterinary Medicine, Ankara University, Ankara, Turkey.; Walkinton O; Vets Beyond Borders, The Rocks, Australia.; Wang J; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK.; Wehrle-Martinez AS; Faculty of Veterinary Sciences, National University of Asuncion, San Lorenzo, Paraguay.; Widdowson SAE; Lilongwe Society for Protection and Care of Animals (LSPCA), Lilongwe, Malawi.; Stratton MR; Wellcome Sanger Institute, Hinxton, UK.; Alexandrov LB; Department of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, CA, USA.; Martincorena I; Wellcome Sanger Institute, Hinxton, UK.; Murchison EP; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Cambridge, UK. epm27@cam.ac.uk.
Source
Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE
Subject
Language
English
Abstract
The canine transmissible venereal tumor (CTVT) is a cancer lineage that arose several millennia ago and survives by "metastasizing" between hosts through cell transfer. The somatic mutations in this cancer record its phylogeography and evolutionary history. We constructed a time-resolved phylogeny from 546 CTVT exomes and describe the lineage's worldwide expansion. Examining variation in mutational exposure, we identify a highly context-specific mutational process that operated early in the cancer's evolution but subsequently vanished, correlate ultraviolet-light mutagenesis with tumor latitude, and describe tumors with heritable hyperactivity of an endogenous mutational process. CTVT displays little evidence of ongoing positive selection, and negative selection is detectable only in essential genes. We illustrate how long-lived clonal organisms capture changing mutagenic environments, and reveal that neutral genetic drift is the dominant feature of long-term cancer evolution.
(Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)
(Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.)