학술논문
The Association Between Genetic Variants in ACE1and ACE2 Genes with Susceptibility to COVID-19 Infection.
Document Type
Academic Journal
Author
Abbaszadeh H; Department of Oral and Maxillofacial Pathology, Faculty of Dentistry, Birjand University of Medical Sciences, Birjand, Iran.; Kabiri-Rad H; Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.; Mohammadi F; Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.; Zangoie S; Department of Biochemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran.; Rajabi-Moghaddam M; Department of Pathology, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran.; Ghafari S; Cellular and Molecular Research Center, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran.; Ziaee M; Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.; Javanmard D; Infectious Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.; Miri-Moghaddam E; Department of Molecular Medicine, Faculty of Medicine, Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran, 9717853577. miri4@bums.ac.ir.
Source
Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 0126611 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4927 (Electronic) Linking ISSN: 00062928 NLM ISO Abbreviation: Biochem Genet Subsets: MEDLINE
Subject
Language
English
Abstract
Angiotensin-converting enzyme 2 (ACE2) receptors facilitate the entry of the causative virus severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) into target cells. Some ACE gene variants have been suggested to be involved in COVID-19 pathogenesis. So, the aim was to assess the association between ACE1 rs4646994 and ACE2 rs2285666 genes polymorphisms and the susceptibility and severity of COVID-19. This case-control study was conducted on 197 patients with COVID-19 and 197 healthy controls. ACE-1 insertion/deletion (I/D) (rs4646994) and ACE2 rs2285666 genes polymorphisms were determined by the amplification refractory mutation system- polymerase chain reaction (ARMS-PCR) technique. The DD genotype of ACE1 I/D polymorphism was associated with increased susceptibility to COVID-19 infection (p = 0.012), whereas the ID genotype of this polymorphism was associated with decreased susceptibility (p = 0.003) (significance level = 0.017). There was no significant association in allele and genotype distribution of ACE2 rs2285666 polymorphism between cases and controls. The ACE1 I/D polymorphism may be considered as a risk factor for COVID-19 susceptibility.
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
(© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)