학술논문
Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study.
Document Type
Academic Journal
Author
van Galen KA; Amsterdam UMC, location AMC, Department of Radiology and Nuclear Medicine, Amsterdam, the Netherlands.; Schrantee A; Amsterdam UMC, location AMC, Department of Radiology and Nuclear Medicine, Amsterdam, the Netherlands.; Ter Horst KW; Amsterdam University Medical Centers (UMC), location AMC, Department of Endocrinology and Metabolism and Amsterdam Gastroenterology Metabolism Endocrinology Institute, Amsterdam, the Netherlands.; la Fleur SE; Amsterdam University Medical Centers (UMC), location AMC, Department of Endocrinology and Metabolism and Amsterdam Gastroenterology Metabolism Endocrinology Institute, Amsterdam, the Netherlands.; Amsterdam UMC, location AMC, Department of Clinical Chemistry, Laboratory of Endocrinology, Amsterdam, the Netherlands.; Booij J; Amsterdam UMC, location AMC, Department of Radiology and Nuclear Medicine, Amsterdam, the Netherlands.; Constable RT; Yale University School of Medicine, Department of Radiology and Biomedical Imaging, New Haven, CT, USA.; Schwartz GJ; Albert Einstein College of Medicine, Fleischer Institute for Diabetes and Metabolism, Bronx, NY, USA.; DiLeone RJ; Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA.; Serlie MJ; Amsterdam University Medical Centers (UMC), location AMC, Department of Endocrinology and Metabolism and Amsterdam Gastroenterology Metabolism Endocrinology Institute, Amsterdam, the Netherlands. mireille.serlie@yale.edu.; Yale University School of Medicine, Department of Endocrinology, New Haven, CT, USA. mireille.serlie@yale.edu.
Source
Publisher: Springer Nature Country of Publication: Germany NLM ID: 101736592 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2522-5812 (Electronic) Linking ISSN: 25225812 NLM ISO Abbreviation: Nat Metab Subsets: MEDLINE
Subject
Language
English
Abstract
Post-ingestive nutrient signals to the brain regulate eating behaviour in rodents, and impaired responses to these signals have been associated with pathological feeding behaviour and obesity. To study this in humans, we performed a single-blinded, randomized, controlled, crossover study in 30 humans with a healthy body weight (females N = 12, males N = 18) and 30 humans with obesity (females N = 18, males N = 12). We assessed the effect of intragastric glucose, lipid and water (noncaloric isovolumetric control) infusions on the primary endpoints cerebral neuronal activity and striatal dopamine release, as well as on the secondary endpoints plasma hormones and glucose, hunger scores and caloric intake. To study whether impaired responses in participants with obesity would be partially reversible with diet-induced weight loss, imaging was repeated after 10% diet-induced weight loss. We show that intragastric glucose and lipid infusions induce orosensory-independent and preference-independent, nutrient-specific cerebral neuronal activity and striatal dopamine release in lean participants. In contrast, participants with obesity have severely impaired brain responses to post-ingestive nutrients. Importantly, the impaired neuronal responses are not restored after diet-induced weight loss. Impaired neuronal responses to nutritional signals may contribute to overeating and obesity, and ongoing resistance to post-ingestive nutrient signals after significant weight loss may in part explain the high rate of weight regain after successful weight loss.
(© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)
(© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)