학술논문
Air Pollution and Systemic Inflammation in Patients With Suspected OSA Living in an Urban Residential Area.
Document Type
Academic Journal
Author
Laratta CR; Leon Judah Blackmore Sleep Disorders Program, University of British Columbia, Vancouver, BC, Canada; Department of Medicine, University of Alberta, Edmonton, AB, Canada.; Kendzerska T; Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada; Department of Medicine, University of Ottawa, Ottawa, ON, Canada.; Carlsten C; Department of Medicine, University of British Columbia, Vancouver, BC, Canada; School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.; Brauer M; Department of Medicine, University of British Columbia, Vancouver, BC, Canada.; van Eeden SF; Department of Medicine, University of British Columbia, Vancouver, BC, Canada; Centre for Heart Lung Innovation, St Paul's Hospital, Vancouver, BC, Canada.; Allen AJMH; Leon Judah Blackmore Sleep Disorders Program, University of British Columbia, Vancouver, BC, Canada.; Fox N; Department of Medicine, University of British Columbia, Vancouver, BC, Canada.; Peres BU; Faculty of Dentistry, Department of Oral Health Sciences, University of British Columbia, Vancouver, BC, Canada.; Ayas NT; Leon Judah Blackmore Sleep Disorders Program, University of British Columbia, Vancouver, BC, Canada; Department of Medicine, University of British Columbia, Vancouver, BC, Canada; Canadian Sleep and Circadian Network. Electronic address: nayas@providencehealth.bc.ca.
Source
Publisher: Elsevier Country of Publication: United States NLM ID: 0231335 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1931-3543 (Electronic) Linking ISSN: 00123692 NLM ISO Abbreviation: Chest Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Air pollution and OSA are independently associated with systemic inflammation, but it is unknown if these exposures interact to influence systemic inflammation.
Research Question: The study objective was to determine the relative importance of these factors and their combined potential to influence systemic inflammation in patients under assessment for sleep ailments.
Study Design and Methods: A total of 315 patients contributed data, including a questionnaire, polysomnogram, and morning serum IL-6 and IL-10 concentrations. For each patient, residential annual average air pollution exposure (nitrogen dioxide [NO2 ], black carbon [BC], and particulate matter with an aerodynamic diameter ≤ 2.5 μm [PM 2.5 ]) was estimated with a land use regression model. Linear regression modeling was used adjusting for age, sex, apnea-hypopnea index, BMI, smoking, socioeconomic status, and comorbidities.
Results: In adjusted models, quartile 4 PM2.5 exposure (compared with quartiles 1-3) was associated with increased IL-6 and IL-10 concentrations (estimated adjusted, 7.1 pg/mL [95% CI, 2.5-11.7; P < .01] and 71.4 pg/mL [95% CI, 38.2-103.7; P < .0001], respectively). OSA, BC, and NO 2 were not associated with IL-6 or IL-10 in similar analyses; however, moderate to severe OSA influenced the effect of BC on IL-6 (interaction term, P = .01), with no significant interaction terms observed for NO 2 or PM 2.5 . Subsequent stratified analysis showed that in the 173 patients with moderate to severe OSA, quartile 4 BC exposure (compared with quartiles 1-3) was associated with an increased IL-6 concentration (estimated adjusted, 8.9 pg/mL; 95% CI, 1.7-16.1; P = .02).
Interpretation: Long-term residential PM2.5 exposure was associated with increased IL-6 and IL-10 concentrations in patients evaluated for suspected OSA. BC exposure was also associated with increased IL-6 but only in the subgroup of patients with moderate to severe OSA. These data suggest the potential for joint effects of moderate to severe OSA and air pollution on systemic inflammation.
(Copyright © 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.)
Research Question: The study objective was to determine the relative importance of these factors and their combined potential to influence systemic inflammation in patients under assessment for sleep ailments.
Study Design and Methods: A total of 315 patients contributed data, including a questionnaire, polysomnogram, and morning serum IL-6 and IL-10 concentrations. For each patient, residential annual average air pollution exposure (nitrogen dioxide [NO
Results: In adjusted models, quartile 4 PM
Interpretation: Long-term residential PM
(Copyright © 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.)