학술논문
Perinatal inflammation exposure and developmental outcomes 7 years after neonatal arterial ischaemic stroke.
Document Type
Academic Journal
Author
Giraud A; INSERM, U1059 SAINBIOSE, Université Jean Monnet, Saint-Étienne, France.; INFANT Research Centre, University College Cork, Cork, Ireland.; Dinomais M; Département de Médecine Physique et de Réadaptation, Centre Hospitalier Universitaire d'Angers, Angers, France.; Garel P; Centre National de Référence de l'AVC de l'Enfant, Médecine Physique et Réadaptation Pédiatrique, INSERM CIC1408, Centre Hospitalier Universitaire de Saint-Étienne, Saint-Étienne, France.; Chevin M; Child Neurology Division, Department of Paediatrics, McGill University, QC, Canada.; Thébault G; Département de Médecine Physique et de Réadaptation, Centre Hospitalier Paul Coste Floret, France.; Renaud C; Centre National de Référence de l'AVC de l'Enfant, Médecine Physique et Réadaptation Pédiatrique, INSERM CIC1408, Centre Hospitalier Universitaire de Saint-Étienne, Saint-Étienne, France.; Presles É; INSERM, U1059 SAINBIOSE, Université Jean Monnet, Saint-Étienne, France.; Unité de Recherche Clinique, Innovation, Pharmacologie, Centre Hospitalier Universitaire de Saint-Étienne, Saint-Étienne, France.; Raia-Barjat T; INSERM, U1059 SAINBIOSE, Université Jean Monnet, Saint-Étienne, France.; Sébire G; Child Neurology Division, Department of Paediatrics, McGill University, QC, Canada.; Chabrier S; INSERM, U1059 SAINBIOSE, Université Jean Monnet, Saint-Étienne, France.; Centre National de Référence de l'AVC de l'Enfant, Médecine Physique et Réadaptation Pédiatrique, INSERM CIC1408, Centre Hospitalier Universitaire de Saint-Étienne, Saint-Étienne, France.
Source
Publisher: Blackwell Country of Publication: England NLM ID: 0006761 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-8749 (Electronic) Linking ISSN: 00121622 NLM ISO Abbreviation: Dev Med Child Neurol Subsets: MEDLINE
Subject
Language
English
Abstract
Aim: To test the association between perinatal inflammation exposure and Full-Scale IQ (FSIQ) score 7 years after neonatal arterial ischaemic stroke (NAIS).
Method: We conducted a cross-sectional ancillary study nested in a multicentric longitudinal French cohort of infants born at term with NAIS between November 2003 and October 2006. Seventy-three children were included (45 males, 28 females). The a priori defined primary outcome measure was the FSIQ score assessed with the Wechsler Intelligence Scale for Children, Fourth Edition at 7 years of age.
Results: Seventeen (23%) of the included children were exposed to perinatal inflammation. Exposure to perinatal inflammation was independently associated with an increase of FSIQ score (coefficient 13.4, 95% confidence interval 1.3-25.4; p = 0.03). Children exposed to perinatal inflammation had a higher median cerebral volume, a lower median lesion volume, and less extensive lesion distributions compared to non-exposed children.
Interpretation: We propose the existence of two NAIS categories: arteritis-associated NAIS in children exposed to perinatal inflammation and embolism-associated NAIS in children non-exposed to perinatal inflammation. Identifying these two NAIS categories would open the possibility for specific curative strategies: anti-inflammatory strategy in arteritis-associated NAIS and recanalization strategy in embolism-associated NAIS.
(© 2023 The Authors. Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press.)
Method: We conducted a cross-sectional ancillary study nested in a multicentric longitudinal French cohort of infants born at term with NAIS between November 2003 and October 2006. Seventy-three children were included (45 males, 28 females). The a priori defined primary outcome measure was the FSIQ score assessed with the Wechsler Intelligence Scale for Children, Fourth Edition at 7 years of age.
Results: Seventeen (23%) of the included children were exposed to perinatal inflammation. Exposure to perinatal inflammation was independently associated with an increase of FSIQ score (coefficient 13.4, 95% confidence interval 1.3-25.4; p = 0.03). Children exposed to perinatal inflammation had a higher median cerebral volume, a lower median lesion volume, and less extensive lesion distributions compared to non-exposed children.
Interpretation: We propose the existence of two NAIS categories: arteritis-associated NAIS in children exposed to perinatal inflammation and embolism-associated NAIS in children non-exposed to perinatal inflammation. Identifying these two NAIS categories would open the possibility for specific curative strategies: anti-inflammatory strategy in arteritis-associated NAIS and recanalization strategy in embolism-associated NAIS.
(© 2023 The Authors. Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press.)