학술논문
Animal Models of Chorioamnionitis: Considerations for Translational Medicine.
Document Type
Academic Journal
Author
Raia-Barjat T; Department of Gynaecology and Obstetrics, University Hospital of Saint-Etienne, 42055 Saint-Etienne, France.; SAnté Ingénierie BIOlogie Saint-Étienne SAINBIOSE, DVH, INSERM U1059, Jean Monnet University, 42000 Saint-Etienne, France.; Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Biosciences and Biotechnology Institute of Grenoble, 38054 Grenoble, France.; Digonnet M; Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Biosciences and Biotechnology Institute of Grenoble, 38054 Grenoble, France.; Biosanté, MAB2 Team, Institut National de la Santé et de la Recherche Médicale U1292, 38000 Grenoble, France.; Giraud A; SAnté Ingénierie BIOlogie Saint-Étienne SAINBIOSE, DVH, INSERM U1059, Jean Monnet University, 42000 Saint-Etienne, France.; Neonatal Intensive Care Unit, Department of Pediatrics, University Hospital of Saint-Etienne, 42055 Saint-Etienne, France.; Ayash T; Child Health and Human Development Program, Child Health Department, Research Institute of McGill University Health Centre, Montreal, QC H4A 3J1, Canada.; Vancolen S; Child Health and Human Development Program, Child Health Department, Research Institute of McGill University Health Centre, Montreal, QC H4A 3J1, Canada.; Benharouga M; Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Biosciences and Biotechnology Institute of Grenoble, 38054 Grenoble, France.; Biosanté, MAB2 Team, Institut National de la Santé et de la Recherche Médicale U1292, 38000 Grenoble, France.; Department of Obstetrics, CS 10217, University Hospital of Grenoble Alpes, 38043 Grenoble, France.; Chauleur C; Department of Gynaecology and Obstetrics, University Hospital of Saint-Etienne, 42055 Saint-Etienne, France.; SAnté Ingénierie BIOlogie Saint-Étienne SAINBIOSE, DVH, INSERM U1059, Jean Monnet University, 42000 Saint-Etienne, France.; Alfaidy N; Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), Biosciences and Biotechnology Institute of Grenoble, 38054 Grenoble, France.; Biosanté, MAB2 Team, Institut National de la Santé et de la Recherche Médicale U1292, 38000 Grenoble, France.; Department of Obstetrics, CS 10217, University Hospital of Grenoble Alpes, 38043 Grenoble, France.; Sébire G; Child Health and Human Development Program, Child Health Department, Research Institute of McGill University Health Centre, Montreal, QC H4A 3J1, Canada.; Department of Pediatrics, McGill University, Montreal, QC H9X 3V9, Canada.
Source
Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101691304 Publication Model: Electronic Cited Medium: Print ISSN: 2227-9059 (Print) Linking ISSN: 22279059 NLM ISO Abbreviation: Biomedicines Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2227-9059
Abstract
Preterm birth is defined as any birth occurring before 37 completed weeks of gestation by the World Health Organization. Preterm birth is responsible for perinatal mortality and long-term neurological morbidity. Acute chorioamnionitis is observed in 70% of premature labor and is associated with a heavy burden of multiorgan morbidities in the offspring. Unfortunately, chorioamnionitis is still missing effective biomarkers and early placento- as well as feto-protective and curative treatments. This review summarizes recent advances in the understanding of the underlying mechanisms of chorioamnionitis and subsequent impacts on the pregnancy outcome, both during and beyond gestation. This review also describes relevant and current animal models of chorioamnionitis used to decipher associated mechanisms and develop much needed therapies. Improved knowledge of the pathophysiological mechanisms underpinning chorioamnionitis based on preclinical models is a mandatory step to identify early in utero diagnostic biomarkers and design novel anti-inflammatory interventions to improve both maternal and fetal outcomes.