학술논문
Structural tissue damage and 24-month progression of semi-quantitative MRI biomarkers of knee osteoarthritis in the IMI-APPROACH cohort.
Document Type
Academic Journal
Author
Roemer FW; Department of Radiology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Maximiliansplatz 3, 91054, Erlangen, Germany. frank.roemer@uk-erlangen.de.; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA. frank.roemer@uk-erlangen.de.; Jansen M; University Medical Center Utrecht, Utrecht, The Netherlands.; Marijnissen ACA; University Medical Center Utrecht, Utrecht, The Netherlands.; Guermazi A; Quantitative Imaging Center, Department of Radiology, Boston University School of Medicine, Boston, MA, USA.; Department of Radiology, VA Boston Healthcare System, West Roxbury, MA, USA.; Heiss R; Department of Radiology, Universitätsklinikum Erlangen and Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Maximiliansplatz 3, 91054, Erlangen, Germany.; Maschek S; Chondrometrics GmbH, Freilassing, Germany.; Department of Imaging & Functional Musculoskeletal Research, Institute of Anatomy & Cell Biology, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria.; Lalande A; Institut de Recherches Internationales Servier, Suresnes, France.; Blanco FJ; Servicio de Reumatologia, INIBIC- Universidade de A Coruña, A Coruña, Spain.; Berenbaum F; Department of Rheumatology, AP-HP Saint-Antoine Hospital, Paris, France.; INSERM, Sorbonne University, Paris, France.; van de Stadt LA; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.; Kloppenburg M; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands.; Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.; Haugen IK; Division of Rheumatology and Research, Diakonhjemmet Hospital, Oslo, Norway.; Ladel CH; Independent Consultant, Darmstadt, Germany.; Bacardit J; School of Computing, Newcastle University, Newcastle, UK.; Wisser A; Chondrometrics GmbH, Freilassing, Germany.; Department of Imaging & Functional Musculoskeletal Research, Institute of Anatomy & Cell Biology, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria.; Ludwig Boltzmann Inst. for Arthritis and Rehabilitation, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria.; Eckstein F; Chondrometrics GmbH, Freilassing, Germany.; Department of Imaging & Functional Musculoskeletal Research, Institute of Anatomy & Cell Biology, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria.; Ludwig Boltzmann Inst. for Arthritis and Rehabilitation, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria.; Lafeber FPJG; University Medical Center Utrecht, Utrecht, The Netherlands.; Weinans HH; University Medical Center Utrecht, Utrecht, The Netherlands.; Wirth W; Chondrometrics GmbH, Freilassing, Germany.; Department of Imaging & Functional Musculoskeletal Research, Institute of Anatomy & Cell Biology, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria.; Ludwig Boltzmann Inst. for Arthritis and Rehabilitation, Paracelsus Medical University Salzburg & Nuremberg, Salzburg, Austria.
Source
Publisher: BioMed Central Country of Publication: England NLM ID: 100968565 Publication Model: Electronic Cited Medium: Internet ISSN: 1471-2474 (Electronic) Linking ISSN: 14712474 NLM ISO Abbreviation: BMC Musculoskelet Disord Subsets: MEDLINE
Subject
Language
English
Abstract
Background: The IMI-APPROACH cohort is an exploratory, 5-centre, 2-year prospective follow-up study of knee osteoarthritis (OA). Aim was to describe baseline multi-tissue semiquantitative MRI evaluation of index knees and to describe change for different MRI features based on number of subregion-approaches and change in maximum grades over a 24-month period.
Methods: MRIs were acquired using 1.5 T or 3 T MRI systems and assessed using the semi-quantitative MRI OA Knee Scoring (MOAKS) system. MRIs were read at baseline and 24-months for cartilage damage, bone marrow lesions (BML), osteophytes, meniscal damage and extrusion, and Hoffa- and effusion-synovitis. In descriptive fashion, the frequencies of MRI features at baseline and change in these imaging biomarkers over time are presented for the entire sample in a subregional and maximum score approach for most features. Differences between knees without and with structural radiographic (R) OA are analyzed in addition.
Results: Two hundred eighty-nine participants had readable baseline MRI examinations. Mean age was 66.6 ± 7.1 years and participants had a mean BMI of 28.1 ± 5.3 kg/m2 . The majority (55.3%) of included knees had radiographic OA. Any change in total cartilage MOAKS score was observed in 53.1% considering full-grade changes only, and in 73.9% including full-grade and within-grade changes. Any medial cartilage progression was seen in 23.9% and any lateral progression on 22.1%. While for the medial and lateral compartments numbers of subregions with improvement and worsening of BMLs were very similar, for the PFJ more improvement was observed compared to worsening (15.5% vs. 9.0%). Including within grade changes, the number of knees showing BML worsening increased from 42.2% to 55.6%. While for some features 24-months change was rare, frequency of change was much more common in knees with vs. without ROA (e.g. worsening of total MOAKS score cartilage in 68.4% of ROA knees vs. 36.7% of no-ROA knees, and 60.7% vs. 21.8% for an increase in maximum BML score per knee).
Conclusions: A wide range of MRI-detected structural pathologies was present in the IMI-APPROACH cohort. Baseline prevalence and change of features was substantially more common in the ROA subgroup compared to the knees without ROA.
Trial Registration: Clinicaltrials.gov identification: NCT03883568.
(© 2022. The Author(s).)
Methods: MRIs were acquired using 1.5 T or 3 T MRI systems and assessed using the semi-quantitative MRI OA Knee Scoring (MOAKS) system. MRIs were read at baseline and 24-months for cartilage damage, bone marrow lesions (BML), osteophytes, meniscal damage and extrusion, and Hoffa- and effusion-synovitis. In descriptive fashion, the frequencies of MRI features at baseline and change in these imaging biomarkers over time are presented for the entire sample in a subregional and maximum score approach for most features. Differences between knees without and with structural radiographic (R) OA are analyzed in addition.
Results: Two hundred eighty-nine participants had readable baseline MRI examinations. Mean age was 66.6 ± 7.1 years and participants had a mean BMI of 28.1 ± 5.3 kg/m
Conclusions: A wide range of MRI-detected structural pathologies was present in the IMI-APPROACH cohort. Baseline prevalence and change of features was substantially more common in the ROA subgroup compared to the knees without ROA.
Trial Registration: Clinicaltrials.gov identification: NCT03883568.
(© 2022. The Author(s).)