학술논문
Risk of Cardiovascular Events in People with HIV (PWH) Treated with Integrase Strand-Transfer Inhibitors: The Debate Is Not Over; Results of the SCOLTA Study.
Document Type
Academic Journal
Author
Corti N; Infectious Diseases Unit, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.; Menzaghi B; Unit of Infectious Diseases, ASST della Valle Olona, 21052 Busto Arsizio, Italy.; Orofino G; Division I of Infectious and Tropical Diseases, ASL Città di Torino, 10149 Turin, Italy.; Guastavigna M; Division I of Infectious and Tropical Diseases, ASL Città di Torino, 10149 Turin, Italy.; Lagi F; AOU Infectious and Tropical Diseases, Careggi Hospital, 50134 Florence, Italy.; Di Biagio A; Infectious Diseases Clinic, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.; Department of Health's Sciences (DISSAL), University of Genoa, 16132 Genoa, Italy.; Taramasso L; Infectious Diseases Clinic, IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.; De Socio GV; Unit of Infectious Diseases, Santa Maria Hospital, 06129 Perugia, Italy.; Molteni C; Unit of Infectious Diseases, A. Manzoni Hospital, 23900 Lecco, Italy.; Madeddu G; Unit of Infectious Diseases, Department of Medicine, Surgery and Pharmacy, University of Sassari, 07100 Sassari, Italy.; Salomoni E; Unit of Infectious Diseases, Santa Maria Annunziata Hospital, 50012 Florence, Italy.; Pellicanò GF; Unit of Infectious Diseases, Department of Human Pathology of the Adult and the Developmental Age 'G. Barresi', University of Messina, 98125 Messina, Italy.; Pontali E; Department of Infectious Diseases, Galliera Hospital, 16128 Genoa, Italy.; Bellagamba R; National Institute for Infectious Diseases, Lazzaro Spallanzani Institute for Hospitalization and Care Scientific, 00149 Rome, Italy.; Celesia BM; Unit of Infectious Diseases, Garibaldi Hospital, 95123 Catania, Italy.; Cascio A; Unit of Infectious Diseases, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, Italy.; Sarchi E; Infectious Diseases Unit, S. Antonio e Biagio e Cesare Arrigo Hospital, 15121 Alessandria, Italy.; Gulminetti R; Fondazione IRCCS Policlinico S. Matteo, Infectious Diseases, University of Pavia, 27100 Pavia, Italy.; Calza L; Department of Medical and Surgical Sciences, Clinics of Infectious Diseases, S. Orsola-Malpighi Hospital, 'Alma Mater Studiorum', University of Bologna, 40128 Bologna, Italy.; Maggi P; Infectious Diseases Unit, AORN Sant'Anna e San Sebastiano, 81100 Caserta, Italy.; Cenderello G; Infectious Diseases Department, Sanremo Hospital, 18038 Sanremo, Italy.; Bandera A; Infectious Disease Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.; Carleo MA; Infectious Diseases and Gender Medicine Unit, Cotugno Hospital, AO dei Colli, 80131 Naples, Italy.; Falasca K; Clinic of Infectious Diseases, Department of Medicine and Science of Aging, G. D'Annunzio University, Chieti-Pescara, 66100 Chieti, Italy.; Ferrara S; Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy.; Martini S; Infectious Disease Unit, University Hospital Luigi Vanvitelli, 80138 Naples, Italy.; Guadagnino G; Department of Infectious and Tropical Diseases, St. Annunziata Hospital, 87100 Cosenza, Italy.; Angioni G; Infectious Diseases Unit, SS Trinità Hospital, 09121 Cagliari, Italy.; Bargiacchi O; Unit of Infectious Diseases, Ospedale Maggiore della Carità, 28100 Novara, Italy.; Ricci ED; Fondazione A.S.I.A. Onlus, 20090 Buccinasco, Italy.; Squillace N; Infectious Diseases Unit, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.; Bonfanti P; Infectious Diseases Unit, Fondazione IRCCS San Gerardo dei Tintori, 20900 Monza, Italy.; School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy.
Source
Publisher: MDPI Country of Publication: Switzerland NLM ID: 101509722 Publication Model: Electronic Cited Medium: Internet ISSN: 1999-4915 (Electronic) Linking ISSN: 19994915 NLM ISO Abbreviation: Viruses Subsets: MEDLINE
Subject
Language
English
Abstract
Cardiovascular disease (CVD) is common in people with HIV (PWH), and has great impact in terms of morbidity and mortality. Several intertwined mechanisms are believed to play a role in determining the increased risk of CVD, including the effect of certain antiretrovirals; among these, the role of integrase strand-transfer inhibitors (INSTIs) is yet to be fully elucidated. We conducted a multicenter, observational study comprising 4984 PWH evaluating the antiretroviral therapy (ART)-related nature of CVD in real life settings, both in naïve vs. treatment-experienced people. A comparison was conducted between INSTIs vs. either protease inhibitors (PIs) or non-nucleoside reverse transcriptase inhibitors (NNRTIs) considering demographic, baseline clinical characteristics, incidence of CVD in both 2-year and complete follow-up periods. Among 2357 PWH exposed to INSTIs, 24 people experienced CVD; the corresponding figure was 12 cases out of 2599 PWH exposed to other ART classes. At univariate and multivariate analysis, a tendency towards an increased risk of CVD was observed in the 2-year follow-up period in PWH exposed to INSTIs in the absence, however, of statistical significance. These findings leave open the hypothesis that INSTIs may play a role, albeit minimal, in determining an increased risk of CVD in PWH.