학술논문
The International Association for the Study of Lung Cancer Thymic Epithelial Tumor Staging Project: Proposal for the T Component for the Forthcoming (Ninth) Edition of the TNM Classification of Malignant Tumors.
Document Type
Academic Journal
Author
Okumura M; National Hospital Organization Osaka Toneyama Medical Center, Osaka, Japan.; Marino M; IRCCS Regina Elena National Cancer Institute, Rome, Italy.; Cilento V; Cancer Research And Biostatistics (CRAB), Seattle, Washington.; Goren E; Cancer Research And Biostatistics (CRAB), Seattle, Washington.; Ruffini E; University of Torino, Torino, Italy. Electronic address: enrico.ruffini@unito.it.; Dibaba D; Cancer Research And Biostatistics (CRAB), Seattle, Washington.; Ahmad U; Thoracic Surgery in the Heart, Vascular & Thoracic Institute at Cleveland Clinic, Abu Dhabi, United Arab Emirates.; Appel S; Sheba Medical Center, Ramat Gan, Israel.; Bille A; Guy's Hospital, London, United Kingdom.; Boubia S; University Hospital Ibn Rochd, Casablanca, Morocco.; Brambilla C; Royal Brompton and Harefield NHS Hospitals, Guy's and St. Thomas' NHS Foundation Trust and National Heart and Lung Institute, Imperial College, London, United Kingdom.; Cangir AK; Ankara University Faculty of Medicine, Ankara, Turkey.; Detterbeck F; Yale University School of Medicine, New Haven, Connecticut.; Falkson C; Queen's University in Kingston, Ontario, Canada.; Fang W; Shanghai Chest Hospital, Jiaotong University Medical School, Shanghai, People's Republic of China.; Filosso PL; Baggiovara Civil Hospital, University of Modena, Modena, Italy.; Giaccone G; Meyer Cancer Center, Weill-Cornell Medicine, New York, New York.; Girard N; Institut Curie, Thorax Institute Curie Montsouris, Paris, France; Paris Saclay University, UVSQ, Versailles, France.; Guerrera F; University of Torino, Torino, Italy.; Huang J; Memorial Sloan Kettering Cancer Center, New York, New York.; Infante M; University and Hospital Trust, Verona, Italy.; Kim DK; Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.; Lucchi M; Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy.; Marom EM; Department of Diagnostic Imaging, Chaim Sheba Medical Center, Tel-Aviv University, Ramat Gan, Israel.; Nicholson AG; Royal Brompton and Harefield NHS Hospitals, Guy's and St. Thomas' NHS Foundation Trust and National Heart and Lung Institute, Imperial College, London, United Kingdom.; Rami-Porta R; Hospital Universitari Mutua Terrassa, Terrassa, Spain; Network of Centers for Biomedical Research in Respiratory Diseases (CIBERES) Lung Cancer Group, Terrassa, Spain.; Rimner A; Memorial Sloan Kettering Cancer Center, New York, New York.; Simone CB 2nd; Memorial Sloan Kettering Cancer Center, New York, New York.; Asamura H; Keio University, Tokyo, Japan; Present Address: Tokyo Dental College Ichikawa General Hospital, Chiba, Japan.
Source
Publisher: Elsevier Country of Publication: United States NLM ID: 101274235 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1556-1380 (Electronic) Linking ISSN: 15560864 NLM ISO Abbreviation: J Thorac Oncol Subsets: MEDLINE
Subject
Language
English
Abstract
Introduction: A TNM-based stage classification system of thymic epithelial tumors was adopted for the eighth edition of the stage classification of malignant tumors. The Thymic Domain of the Staging and Prognostics Factor Committee of the International Association for the Study of Lung Cancer developed a new database with the purpose to make proposals for the ninth edition stage classification system. This article outlines the proposed definitions for the T categories for the ninth edition TNM stage classification of thymic malignancies.
Methods: A worldwide collective database of 11,347 patients with thymic epithelial tumors was assembled. Analysis was performed on 9147 patients with available survival data. Overall survival, freedom-from-recurrence, and cumulative incidence of recurrence were used as outcome measures. Analysis was performed separately for thymomas, thymic carcinomas, and neuroendocrine thymic tumors.
Results: Proposals for the T categories include the following: T1 category is divided into T1a (≤5 cm) and T1b (>5 cm), irrespective of mediastinal pleura invasion; T2 includes direct invasion of the pericardium, lung, or phrenic nerve; T3 denotes direct invasion of the brachiocephalic vein, superior vena cava, chest wall, or extrapericardial pulmonary arteries and veins; and T4 category remains the same as in the eighth edition classification, involving direct invasion of the aorta and arch vessels, intrapericardial pulmonary arteries and veins, myocardium, trachea, or esophagus.
Conclusions: The proposed T categories for the ninth edition of the TNM classification provide good discrimination in outcome for the T component of the TNM-based stage system of thymic epithelial tumors.
(Copyright © 2023. Published by Elsevier Inc.)
Methods: A worldwide collective database of 11,347 patients with thymic epithelial tumors was assembled. Analysis was performed on 9147 patients with available survival data. Overall survival, freedom-from-recurrence, and cumulative incidence of recurrence were used as outcome measures. Analysis was performed separately for thymomas, thymic carcinomas, and neuroendocrine thymic tumors.
Results: Proposals for the T categories include the following: T1 category is divided into T1a (≤5 cm) and T1b (>5 cm), irrespective of mediastinal pleura invasion; T2 includes direct invasion of the pericardium, lung, or phrenic nerve; T3 denotes direct invasion of the brachiocephalic vein, superior vena cava, chest wall, or extrapericardial pulmonary arteries and veins; and T4 category remains the same as in the eighth edition classification, involving direct invasion of the aorta and arch vessels, intrapericardial pulmonary arteries and veins, myocardium, trachea, or esophagus.
Conclusions: The proposed T categories for the ninth edition of the TNM classification provide good discrimination in outcome for the T component of the TNM-based stage system of thymic epithelial tumors.
(Copyright © 2023. Published by Elsevier Inc.)