학술논문
ROS1 Rearrangement in a Case of Classic Biphasic Pulmonary Blastoma.
Document Type
Academic Journal
Author
Jenkins TM; 1 Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Morrissette JJD; 1 Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Kucharczuk JC; 1 Hospital of the University of Pennsylvania, Philadelphia, PA, USA.; Deshpande CG; 1 Hospital of the University of Pennsylvania, Philadelphia, PA, USA.
Source
Publisher: Sage Publications Country of Publication: United States NLM ID: 9314927 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1940-2465 (Electronic) Linking ISSN: 10668969 NLM ISO Abbreviation: Int J Surg Pathol Subsets: MEDLINE
Subject
Language
English
Abstract
Classic biphasic pulmonary blastoma (CBPB) is a rare and aggressive type of non-small cell lung carcinoma (NSCLC) presenting in adults in the fourth to fifth decade. The prognosis is poor and after surgical resection, therapeutic options are often limited. ROS1 is a proto-oncogene receptor tyrosine kinase that has been identified in some types of NSCLC. We report a case of a 36-year-old woman with CBPB, which was subsequently found to have a ROS1 rearrangement. This is the first reported case of a ROS1-rearranged CBPB. This finding has therapeutic implications as these tumors have the potential to be treated with receptor tyrosine kinase inhibitors.