학술논문
Diffusion tensor imaging in pediatric patients with dystonia.
Document Type
Academic Journal
Author
Loução R; Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, Kerpener Straße 62, Cologne 50937, Germany; Department of Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. Electronic address: ricardo.loucao@uk-koeln.de.; Burkhardt J; Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, Kerpener Straße 62, Cologne 50937, Germany.; Wirths J; Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, Kerpener Straße 62, Cologne 50937, Germany.; Kabbasch C; Department of Radiology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Dembek TA; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Heiden P; Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, Kerpener Straße 62, Cologne 50937, Germany; Department of Neurosurgery, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Cirak S; Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.; Al-Fatly B; Department of Neurology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.; Treuer H; Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, Kerpener Straße 62, Cologne 50937, Germany.; Visser-Vandewalle V; Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, Kerpener Straße 62, Cologne 50937, Germany.; Hoevels M; Department of Stereotactic and Functional Neurosurgery, Faculty of Medicine and University Hospital Cologne, Kerpener Straße 62, Cologne 50937, Germany.; Koy A; Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany.
Source
Publisher: Academic Press Country of Publication: United States NLM ID: 9215515 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9572 (Electronic) Linking ISSN: 10538119 NLM ISO Abbreviation: Neuroimage Subsets: MEDLINE
Subject
Language
English
Abstract
Background: Childhood-onset dystonia is often progressive and severely impairs a child´s life. The pathophysiology is very heterogeneous and treatment responses vary in patients with dystonia. Factors influencing treatment effects remain to be elucidated. We hypothesize that differences in brain connectivity and fiber coherence contribute to the heterogeneity in treatment response among pediatric patients with inherited and acquired dystonia.
Methods: Twenty patients with childhood-onset dystonia were retrospectively recruited including twelve patients with inherited or idiopathic, and eight patients with acquired dystonia (mean age 10 years; 8 female/12 male). Fiber density between the internal part of the globus pallidus and selective target regions, as well as the diffusion measures of fractional anisotropy (FA) and mean diffusivity (MD) were analyzed and compared between different etiologies.
Results: Patients with acquired dystonia presented higher fiber density to the premotor cortex and putamen and lower FA values in the thalamus compared to patients with inherited/idiopathic dystonia. MD in the premotor cortex was higher in patients with acquired dystonia, while it was lower in the thalamus.
Conclusion: Diffusion MRI reveals microstructural and network alterations in patients with dystonia of different etiologies.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Anne Koy reports financial support was provided by Dr. Hans Günther and Dr. Rita Herfort Foundation. Anne Koy reports financial support was provided by Boston Scientific Neuromodulation. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Inc.)
Methods: Twenty patients with childhood-onset dystonia were retrospectively recruited including twelve patients with inherited or idiopathic, and eight patients with acquired dystonia (mean age 10 years; 8 female/12 male). Fiber density between the internal part of the globus pallidus and selective target regions, as well as the diffusion measures of fractional anisotropy (FA) and mean diffusivity (MD) were analyzed and compared between different etiologies.
Results: Patients with acquired dystonia presented higher fiber density to the premotor cortex and putamen and lower FA values in the thalamus compared to patients with inherited/idiopathic dystonia. MD in the premotor cortex was higher in patients with acquired dystonia, while it was lower in the thalamus.
Conclusion: Diffusion MRI reveals microstructural and network alterations in patients with dystonia of different etiologies.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Anne Koy reports financial support was provided by Dr. Hans Günther and Dr. Rita Herfort Foundation. Anne Koy reports financial support was provided by Boston Scientific Neuromodulation. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier Inc.)