학술논문
Suspected Buprenorphine-Precipitated Opioid Withdrawal following Intercourse: A Case Report.
Document Type
Academic Journal
Author
Lynch D; Department of Anesthesia UF Health Jacksonville, University of Florida-Jacksonville, Jacksonville, FL, USA.; Chitty L; Department of Anesthesia UF Health Jacksonville, University of Florida-Jacksonville, Jacksonville, FL, USA.; Johnson B; Department of Pharmacy UF Health Jacksonville, University of Florida-Jacksonville, Jacksonville, FL, USA.; Hoefnagel AL; Department of Anesthesia UF Health Jacksonville, University of Florida-Jacksonville, Jacksonville, FL, USA.
Source
Publisher: Informa Healthcare Country of Publication: England NLM ID: 101125608 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-0539 (Electronic) Linking ISSN: 15360288 NLM ISO Abbreviation: J Pain Palliat Care Pharmacother Subsets: MEDLINE
Subject
Language
English
Abstract
Buprenorphine, a partial mu-opioid receptor agonist, is a commonly prescribed medication for opioid use disorder (OUD). There is evidence that drugs may enter the male genitourinary tract by an ion-trapping process, based on the lipid solubility and degree of ionization (1). While little is known about the pharmacokinetics of drugs in seminal fluid, pH is thought to play an integral role. Limited evidence exists surrounding cervical absorption of drugs via seminal fluid transmission. This also prompts survey of the frequency of this event and the influence on treatment within this population.