학술논문
Assessment of the fitness of Cox and parametric regression models of survival distribution for Iranian breast cancer patients' data.
Document Type
Academic Journal
Author
Mohseny M; Departments of Health and Community Medicine, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Shekarriz-Foumani R; Department of Community Medicine, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Amiri P; Iranian Research Center on Healthy Aging, Sabzevar University of Medical Sciences, Sabzevar, Iran.; Vejdani M; Iranian Research Center on Healthy Aging, Sabzevar University of Medical Sciences, Sabzevar, Iran.; Farshidmehr P; Department of Vascular Surgery, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.; Mahmoudabadi HZ; Department of Surgery, School of Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.; Amanpour F; Department of Epidemiology and Biostatistics, School of Public Health, Shahroud University of Medical Sciences, Shahroud, Iran.; Mohaghegh P; Department of Community Medicine, School of Medicine, Arak University of Medical Sciences, Arak, Iran.; Tajdini F; Departments of Health and Community Medicine, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Sayarifard A; Community Based Participatory Research Center, Iranian Institute for Reduction of High-Risk Behaviors, Tehran University of Medical Sciences, Tehran, Iran.; Davoudi-Monfared E; Health Management Research Center & Department of Community Medicine, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran.
Source
Publisher: Medknow on behalf of Society of Pharmaceutical Education & Research Country of Publication: India NLM ID: 101537797 Publication Model: Print Cited Medium: Print ISSN: 2231-4040 (Print) Linking ISSN: 09762094 NLM ISO Abbreviation: J Adv Pharm Technol Res Subsets: PubMed not MEDLINE
Subject
Language
English
ISSN
2231-4040
Abstract
Factors affecting the time of survival after breast cancer (BC) diagnosis remain unknown. However, some of the prognostic factors have been identified. The aim of this study was to investigate the effects of biologic and socioeconomic factors on long-term survival of BC patients. This was a descriptive chart review and survey of all women with a confirmed diagnosis of BC registered in Shohada-e-Tajrish Cancer Research Center database from March 2004 to March 2015. The checklist of study consisted of biologic, demographic, reproductive, genetic, medical, and therapeutic information of patients. The minimum time of follow-up was 3 years and the maximum was 10 years. We then evaluated possible associations of these variables with BC survival using Cox and parametric regression models of survival analysis. The study population was 1276 BC patients. Their mean survival was 23 (range 1-120) months. Between the parametric models, Weibull regression model demonstrated the lowest Akaike information criterion and thus the best fit, and tumor size, number of lymph nodes, BC stage, educational level, and high-fat diet were significant in this model. Based on our findings, educational level, consumption of fat, and characteristics of tumor at the time of diagnosis (disease stage, tumor size, number of involved lymph nodes) are the most important prognostic factors affecting long-term survival of BC patients. We suggest that future studies assess the efficacy of possible interventions for these factors.
Competing Interests: There are no conflicts of interest.
Competing Interests: There are no conflicts of interest.