학술논문
Complexes of nalidixic acid with some vital metal ions: Synthesis, chemical structure elucidation, and antimicrobial evaluation.
Document Type
Article
Source
Subject
*ANTI-infective agents
*PYRIDINE
*CARBONYL compounds
*SPECTRUM analysis
*SPECTROMETRY
*
*
*
*
Language
ISSN
1070-3632
Abstract
Complexes of nalidixic acid with Ca(II), Mg(II), Zn(II), Fe(III), and VO(II) ions, have been synthesized and characterized by means of microanalysis, conductance, IR, NMR and UV-Vis spectroscopy and thermogravimetric (TGA/DTG and DTA) measurements. The ligand coordinates in a bidentate mode via one carboxylate oxygen atom and the oxygen atom of the pyridine carbonyl group. The kinetic thermodynamic parameters such as: activation energy E*, Δ H*, Δ S*, and Δ G* have been estimated using Coats and Redfern as well as Horowitz-Metzger equations. Antimicrobial activity of the obtained complexes against some kinds of bacteria and fungi has been evaluated. [ABSTRACT FROM AUTHOR]