학술논문
Opinion: Mechanisms of roof plate formation in the vertebrate CNS.
Document Type
Article
Source
Subject
*NEURAL tube
*CENTRAL nervous system
*VERTEBRATES
*CELLS
*NEURONS
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*
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Language
ISSN
1471-003X
Abstract
The roof plate is an embryonic organizing centre that occupies the dorsal midline of the vertebrate neural tube. During early CNS development, the roof plate produces secreted factors, which control the specification and differentiation of dorsal neuronal cell types. An appreciation of the signalling properties of the roof plate has prompted an enhanced interest in this important organizing centre, and several recent studies have begun to illuminate the molecular mechanisms of roof plate development. [ABSTRACT FROM AUTHOR]