학술논문
Innovations in phenotyping of mouse models in the German Mouse Clinic.
Document Type
Article
Author
Fuchs, Helmut; Gailus-Durner, Valérie; Neschen, Susanne; Adler, Thure; Afonso, Luciana; Aguilar-Pimentel, Juan; Becker, Lore; Bohla, Alexander; Calzada-Wack, Julia; Cohrs, Christian; Dewert, Anna; Fridrich, Barbara; Garrett, Lillian; Glasl, Lisa; Götz, Alexander; Hans, Wolfgang; Hölter, Sabine; Horsch, Marion; Hurt, Anja; Janas, Eva
Source
Subject
*COMPUTING platforms
*PHENOTYPES
*SCIENTIFIC community
*LABORATORY mice
*ANIMAL models in research
*MUTAGENESIS
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Language
ISSN
0938-8990
Abstract
Under the label of the German Mouse Clinic (GMC), a concept has been developed and implemented that allows the better understanding of human diseases on the pathophysiological and molecular level. This includes better understanding of the crosstalk between different organs, pleiotropy of genes, and the systemic impact of envirotypes and drugs. In the GMC, experts from various fields of mouse genetics and physiology, in close collaboration with clinicians, work side by side under one roof. The GMC is an open-access platform for the scientific community by providing phenotypic analysis in bilateral collaborations ('bottom-up projects') and as a partner and driver in international large-scale biology projects ('top-down projects'). Furthermore, technology development is a major topic in the GMC. Innovative techniques for primary and secondary screens are developed and implemented into the phenotyping pipelines (e.g., detection of volatile organic compounds, VOCs). [ABSTRACT FROM AUTHOR]