학술논문
Structural insights into crista junction formation by the Mic60-Mic19 complex.
Document Type
Article
Author
Bock-Bierbaum, Tobias; Funck, Kathrin; Wollweber, Florian; Lisicki, Elisa; von der Malsburg, Karina; von der Malsburg, Alexander; Laborenz, Janina; Noel, Jeffrey K.; Hessenberger, Manuel; Jungbluth, Sibylle; Bernert, Carola; Kunz, Séverine; Riedel, Dietmar; Lilie, Hauke; Jakobs, Stefan; van der Laan, Martin; Daumke, Oliver
Source
Subject
*LIFE sciences
*LIPID transfer protein
*TANDEM mass spectrometry
*MOLECULAR weights
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Language
ISSN
2375-2548
Abstract
The article discusses research on the role of the Mic60-Mic19 subcomplex of mitochondria which controls crista junctions (CJ) architecture and function. Mic19 promotes Mic60 tetramerization via a conserved interface between the Mic60 mitofilin and Mic19 CHCH domains. Dimerization of mitofilin domains exposes a crescent-shaped membrane-binding site with convex curvature tailored to interact with the curved CJ neck.