학술논문

Sicca syndrome in systemic sclerosis: a narrative review on a neglected issue.
Document Type
Article
Source
Rheumatology. 2023 Supplement, Vol. 62, pSI1-SI11. 11p.
Subject
*SJOGREN'S syndrome diagnosis
*PULMONARY arterial hypertension
*SYSTEMIC scleroderma
*QUALITY of life
*XEROSTOMIA
*SJOGREN'S syndrome
*PULMONARY fibrosis
*SALIVARY glands
*SYMPTOMS
Language
ISSN
1462-0324
Abstract
SSc is an auto-immune disease characterized by life-threatening manifestations such as lung fibrosis or pulmonary arterial hypertension. Symptoms with a detrimental impact on quality of life are also reported and sicca syndrome (xerostomia, xeropthalmia) is present in up to 80% of patients with SSc. Sicca syndrome can occur in the absence of overlap with Sjögren's disease and recent studies highlight that fibrosis of minor and major salivary glands, directly linked to the pathogenesis of SSc, could be a major contributor of xerostomia in SSc. This narrative review provides an overview of the clinical presentation, diagnostic strategies, management and future perspectives on sicca syndrome in patients with SSc. [ABSTRACT FROM AUTHOR]