학술논문
Heat-shock protein (HSP70-2) allelic frequencies in three distinct Mexican populations.
Document Type
Article
Author
Source
Subject
*MAJOR histocompatibility complex
*HEAT shock proteins
*RESTRICTION fragment length polymorphisms
*GENETIC polymorphisms
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Language
ISSN
1466-4879
Abstract
The major histocompatibility complex (MHC) genes are highly polymorphic and therefore have been useful in population genetics and disease association studies. We analyzed restriction fragment length polymorphism of HSP70-2 alleles in healthy unrelated Mestizo, Mazatecan and Nahua populations. Both Indian groups, Mazatecans and Nahuas, were in Hardy-Weinberg equilibrium, while Mestizos were in disequilibrium (X² = 0.399; P < 0.05). The Mazatecan Indians presented a high frequency of BB homozygosity (17.35%) compared to Mestizos (5%) (P= 0.01). Mexican ethnic groups present differences in distribution of BB genotype. The Iow frequency of BB genotype in Mestizos may be the result of a negative selection process. [ABSTRACT FROM AUTHOR]