부산대학교 도서관

The purpose of our study was to reveal the expression of miR-30d-5p and its function in the occurrence and development of acute pancreatitis (AP). Quantitative real-time PCR was used to detect the expression of miR-30d-5p in patients with severe acute pancreatitis (SAP). Pearson correlation analysis was used to substantiate the correlation between miR-30d-5p and laboratory scoring systems, namely the Ranson score and Acute Physiology and Chronic Health Evaluation II (APACHE II) score. The receiver operating characteristic curve was used to illustrate the function of miR-30d-5p in SAP. The predictive roles of miR-30d-5p in the process from mild acute pancreatitis (MAP) to SAP were unveiled by logistic regression. Our result showed the relative expression of miR-30d-5p was elevated in patients with MAP and SAP when compared with control individuals. Pearson correlation analysis documented that the overexpression of miR-30d-5p was related to high APACHE II scores and Ranson scores. In addition, miR-30d-5p might function as a diagnostic indicator and an independent biomarker in the emergence and development of AP. Conclusions: The elevated expression of miR-30d-5p was found in patients with SAP and had positive correlations with the APACHE II score and Ranson score. Moreover, miR-30d-5p might be an alternative index for the diagnosis and progress of SAP. [ABSTRACT FROM AUTHOR]