학술논문
A transient, closed-loop network of wireless, body-integrated devices for autonomous electrotherapy.
Document Type
Article
Author
Yeon Sik Choi; Hyoyoung Jeong; Yin, Rose T.; Avila, Raudel; Pfenniger, Anna; Jaeyoung Yoo; Jong Yoon Lee; Tzavelis, Andreas; Young Joong Lee; Chen, Sheena W.; Knight, Helen S.; Seungyeob Kim; Hak-Young Ahn; Wickerson, Grace; Vázquez-Guardado, Abraham; Higbee-Dempsey, Elizabeth; Russo, Bender A.; Napolitano, Michael A.; Holleran, Timothy J.; Razzak, Leen Abdul
Source
Subject
*CLOSED loop systems
*ELECTROTHERAPEUTICS
*CARDIAC pacing
*CARDIAC pacemakers
*BIOELECTRONICS
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Language
ISSN
0036-8075
Abstract
Temporary postoperative cardiac pacing requires devices with percutaneous leads and external wired power and control systems. This hardware introduces risks for infection, limitations on patient mobility, and requirements for surgical extraction procedures. Bioresorbable pacemakers mitigate some of these disadvantages, but they demand pairing with external, wired systems and secondary mechanisms for control. We present a transient closed-loop system that combines a time-synchronized, wireless network of skin-integrated devices with an advanced bioresorbable pacemaker to control cardiac rhythms, track cardiopulmonary status, provide multihaptic feedback, and enable transient operation with minimal patient burden. The result provides a range of autonomous, rate-adaptive cardiac pacing capabilities, as demonstrated in rat, canine, and human heart studies. This work establishes an engineering framework for closed-loop temporary electrotherapy using wirelessly linked, body-integrated bioelectronic devices. [ABSTRACT FROM AUTHOR]