학술논문
Safety of haem arginate in overdose: report of an uneventful fourfold accidental overdose.
Document Type
Letter
Author
Source
Subject
*HEME
*NALOXONE
*DRUG overdose
*BLOOD cell count
*ACUTE intermittent porphyria
*BLOOD gases
*GLOBIN
*
*
*
*
*
*
Language
ISSN
1556-3650
Abstract
Dear Editor, Severe exacerbations of acute intermittent porphyria (AIP) are treated with haem arginate, which inhibits -aminolaevulinic acid synthase in the liver, reducing the formation of neurotoxic precursors of haem which cause acute attacks [[1]]. Liver transplantation because of acute liver failure due to heme arginate overdose in a patient with acute intermittent porphyria. The proposed mechanism is saturation of the haem binding capacity of albumin and haemopexin with iron released from haem causing hepatic infarction and necrosis [[2]]. [Extracted from the article]