학술논문
Impact of Seasonal Coronavirus Antibodies on Severe Acute Respiratory Syndrome Coronavirus 2 Vaccine Responses in Solid Organ Transplant Recipients.
Document Type
Article
Author
Karaba, Andrew H; Zhou, Weiqiang; Li, Shuai; Aytenfisu, Tihitina Y; Johnston, Trevor S; Akinde, Olivia; Eby, Yolanda; Abedon, Aura T; Alejo, Jennifer L; Qin, Caroline X; Thompson, Elizabeth A; Garonzik-Wang, Jacqueline M; Blankson, Joel N; Cox, Andrea L; Bailey, Justin R; Klein, Sabra L; Pekosz, Andrew; Segev, Dorry L; Tobian, Aaron A R; Werbel, William A
Source
Subject
*SARS-CoV-2
*COVID-19
*SCIENTIFIC observation
*COVID-19 vaccines
*IMMUNOCOMPROMISED patients
*VACCINE immunogenicity
*PATIENTS
*RESEARCH funding
*DESCRIPTIVE statistics
*VIRAL antibodies
*TRANSPLANTATION of organs, tissues, etc.
*LONGITUDINAL method
*
*
*
*
*
*
*
*
*
*
*
Language
ISSN
1058-4838
Abstract
Antibody responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination are reduced in solid organ transplant recipients (SOTRs). We report that increased levels of preexisting antibodies to seasonal coronaviruses are associated with decreased antibody response to SARS-CoV-2 vaccination in SOTRs, supporting that antigenic imprinting modulates vaccine responses in SOTRs. [ABSTRACT FROM AUTHOR]