학술논문
Innate immune sensing by cGAS-STING in animals reveals unexpected messengers.
Document Type
Article
Author
Source
Subject
*IMMUNE response
*SENSES
*DNA
*ADAPTOR proteins
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Language
ISSN
0092-8674
Abstract
The DNA sensor cGAS and its adaptor STING constitute an ancient pathogen detection mechanism, but it is unclear to what extent its function is conserved across the animal kingdom. In this issue of Cell , Kranzusch and colleagues identify thousands of cGAS-like receptors and discover networks of second messengers that activate innate immune responses in animals. [ABSTRACT FROM AUTHOR]